Birth characteristics and the risk of childhood brain tumors: A case-control study in Ontario, Canada.

Various birth characteristics may influence healthy childhood development, including the risk of developing childhood brain tumors (CBTs). In this study, we aimed to investigate the association between delivery methods, obstetric history, and birth anthropometrics with the risk of CBTs. This study used data from the Childhood Brain Tumour Epidemiology Study of Ontario (CBREO) which included children 0-15 years of age and newly diagnosed with CBTs from 1997 to 2003.

Development of genomic evaluation for methane efficiency in Canadian Holsteins.

Reducing methane (CH) emissions from agriculture, among other sectors, is a key step to reducing global warming. There are many strategies to reduce CH emissions in ruminant animals, including genetic selection, which yields cumulative and permanent genetic gains over generations. A single-step genomic evaluation for methane efficiency (MEF) was officially implemented in April 2023 for the Canadian Holstein breed, aiming to reduce CH emissions without affecting production levels.

Coxsackievirus and adenovirus receptor expression facilitates enteroviral infections to drive the development of pancreatic cancer.

The development of pancreatic cancer requires both, acquisition of an oncogenic mutation in KRAS as well as an inflammatory insult. However, the physiological causes for pancreatic inflammation are less defined. We show here that oncogenic KRas-expressing pre-neoplastic lesion cells upregulate coxsackievirus (CVB) and adenovirus receptor (CAR).

CO protects cells from iron-Fenton oxidative DNA damage in and humans.

While hydroxyl radical is commonly named as the Fenton product responsible for DNA and RNA damage in cells, here we demonstrate that the cellular reaction generates carbonate radical anion due to physiological bicarbonate levels. In human and models, their transcriptomes were analyzed by RNA direct nanopore sequencing of ribosomal RNA and chromatography coupled to electrochemical detection to quantify oxidation products in order to follow the bicarbonate dependency in HO-induced oxidation. These transcriptomic studies identified physiologically relevant levels of bicarbonate focused oxidation on the guanine base favorably yielding 8-oxo-7,8-dihydroguanine (OG).