SERS and ECL dual-mode sensing of bacterial lipopolysaccharide based on bifunctional DNA strands mediated transformation from Au@Ag nanocubes to silver nanoclusters.

Bacterial contamination is a very serious health and environmental problem, with the main source of toxicity being lipopolysaccharides in the cell walls of Gram-negative bacteria. Therefore, the development of effective analytical methods is crucial for the detection of lipopolysaccharide content. This work facilitates the efficient generation of precisely adjustable dual-mode signals for LPS detection in surface-enhanced Raman spectroscopy (SERS) and electrochemiluminescence (ECL) by inducing anisotropic morphological evolution of Au@Ag nanocubes (Au@AgNCs) through poly-cytosine (poly-C) DNA.

TGFBI regulates the TGF-β pathway to affect the malignant progression and cisplatin sensitivity in diffuse large B-cell lymphoma.

Despite the association between aberrant TGFBI expression and tumors development found in various cancer types, the role of TGFBI in diffuse large B-cell lymphoma (DLBCL) progression is not clear. This study attempted to reveal how TGFBI impacts malignant progression and cisplatin sensitivity in DLBCL. Bioinformatics and qRT-PCR were used to analyze expression of TGFBI.

Drp1-associated genes implicated in sepsis survival.

Sepsis is a severe and life-threatening medical syndrome that can lead to organ failure and death. Despite advances in medical treatment, current therapies are often inadequate, with high septic mortality rates. Therefore, there is a critical need for reliable prognostic markers to be used in clinical settings to improve the management and outcomes of patients with sepsis.

Reshape Iron Nanoparticles Using a Zinc Oxide Nanowire Array for High Efficiency and Stable Electrocatalytic Nitrogen Fixation.

As a type of century-old catalyst, the use of iron-based materials runs through the Haber-Bosch process and electrochemical synthesis of ammonia because of its excellent capability, low cost, and abundant reserves. How to continuously improve its catalytic activity and stability for electrochemical nitrogen fixation has always been a goal pursued by scientific researchers. Herein, we develop a free-standing iron-based catalyst, i.

Genetic Etiology Link to Brain Function Underlying ADHD Symptoms and its Interaction with Sleep Disturbance: An ABCD Study.

Attention deficit hyperactivity disorder (ADHD), a prevalent neurodevelopmental disorder influenced by both genetic and environmental factors, remains poorly understood regarding how its polygenic risk score (PRS) impacts functional networks and symptomology. This study capitalized on data from 11,430 children in the Adolescent Brain Cognitive Development study to explore the interplay between PRS, brain function, and behavioral problems, along with their interactive effects. The results showed that children with a higher PRS exhibited more severe attention deficits and rule-breaking problems, and experienced sleep disturbances, particularly in initiating and maintaining sleep.