Publications by authors named "A S Fairey"
Background: Neuroendocrine prostate cancer (NEPC) encompasses pure NEPC and tumors with mixed adenocarcinoma and neuroendocrine histology. While NEPC is thought to confer a poor prognosis, outcome data are sparse, making risk stratification and treatment decisions difficult for clinicians.
Methods: This retrospective study identified patients with morphological and/or immunohistochemical NEPC features on pathological review of high-grade prostate cancer cases.
Article Synopsis
- Human interactions with wild animals in zoos and aquariums can be beneficial for education and conservation, but not all interactions are positive for the animals involved.
- A study assessed dysfunctional animal-visitor interactions across 225 facilities in nine Southeast Asian countries, finding harmful practices like animal selfies and rides.
- Accreditation by zoological associations did not significantly reduce these harmful interactions, indicating a need for better strategies, legislation, and guidance to improve standards in animal welfare.
Article Synopsis
- Patients undergoing open radical cystectomy have a high risk of needing blood transfusions, and the study investigates the use of tranexamic acid (TXA) to potentially reduce this risk.
- The TACT trial was a randomized, double-blind study conducted in 10 academic centers from 2013 to 2021, involving patients scheduled for this type of surgery due to bladder cancer.
- Results showed no significant difference in RBC transfusion rates between the TXA group and the placebo group, with both groups needing transfusions at similar rates up to 30 days post-surgery.
Purpose: To report the effects of a 12-week high-intensity interval training (HIIT) program on cardiometabolic biomarkers in patients with prostate cancer on active surveillance (AS) from the Exercise During Active Surveillance for Prostate Cancer (ERASE) Trial.
Methods: Fifty-two men with prostate cancer on AS were randomized to either an exercise (HIIT; n = 26) or usual care (UC; n = 26) group. The HIIT intervention consisted of progressive, supervised, aerobic HIIT at an intensity of 85 to 95% VO for 28 to 40 min per session performed three times/week for 12 weeks.
The current prostate cancer (PCa) screen test, prostate-specific antigen (PSA), has a high sensitivity for PCa but low specificity for high-risk, clinically significant PCa (csPCa), resulting in overdiagnosis and overtreatment of non-csPCa. Early identification of csPCa while avoiding unnecessary biopsies in men with non-csPCa is challenging. We built an optimized machine learning platform (ClarityDX) and showed its utility in generating models predicting csPCa.
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