Publications by authors named "A S Fadilah"

Introduction: Pulmonary arterial hypertension (PAH) is a severe cardiovascular condition characterized by pulmonary vascular remodeling, increased resistance to blood flow, and eventual right heart failure. Right heart catheterization (RHC) is the gold standard diagnostic technique, but due to its invasiveness, it poses risks such as vessel and valve injury. In recent years, machine learning (ML) technologies have offered non-invasive alternatives combined with ML for improving the diagnosis of PAH.

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Background: The neurological examination of an unwell neonate can aid management, such as deciding if hypothermia treatment is warranted in hypoxic ischaemic encephalopathy or directing investigations in hypotonic neonates. Current standardised examinations are not designed for unwell or ventilated neonates, and it is unclear how confident paediatricians feel about the examination or what aspects they perform.  AIM: This study aimed to review the confidence of UK paediatricians on the neurological examination in unwell neonates, describe their attitudes towards it, and determine what could improve practice.

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Article Synopsis
  • MCT8 deficiency is a rare condition affecting thyroid hormone transport in the brain, leading to neurological issues and signs of both peripheral thyrotoxicosis and cerebral hypothyroidism.
  • The study evaluated movement disorders (MDs) in 27 patients, identifying hypokinesia as the most common MD, alongside other disorders like dystonia and exaggerated startle reactions.
  • Findings suggest that MDs are prevalent in MCT8 deficiency, with hypokinesia often being the main concern, possibly due to thyroid hormones' crucial role in brain development and the function of dopaminergic circuits.
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Unlabelled: This observational study describes the procedure technique, safety outcomes, and patient responses to celiac plexus blockade (CPB) in children with severe neurodisability with refractory feed intolerance, feed induced pain or feed induced dystonia (FID).

Method: A review of the pathophysiological response to feeding in children with significant neurodisability and the effect on the neuroenteric system. A 2-stage CT-guided temporary celiac plexus blockade followed by neurolysis technique is described.

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