[Peculiarities of the time of manifestation of a number of diseases in the periods before and after the COVID-19 pandemic according to the data of municipal polyclinics of Sakhalin region.].

The topic of the timing of the manifestation of age-associated diseases (as an indirect indicator of accelerated population aging) after the transfer of COVID-19 remains an urgent area in scientific research. Early targeted diagnosis can significantly reduce the consequences of pathology, in connection with which the features of the manifestation of various nosologies in the post-COVID period were studied. The materials were the accounting and statistical data of the municipal polyclinics of the Sakhalin Region for the pre-COVID (2017-2019) and post-COVID (2022-2023) periods.

Isolation, Characterization, and Unlocking the Potential of Mimir124 Phage for Personalized Treatment of Difficult, Multidrug-Resistant Uropathogenic Strain.

and its bacteriophages are among the most studied model microorganisms. Bacteriophages for various strains can typically be easily isolated from environmental sources, and many of these viruses can be harnessed to combat infections in humans and animals. However, some relatively rare strains pose significant challenges in finding suitable phages.

Complementary Packing of α-Helices Revisited.

The packing of α-helices in proteins is determined by both the principle of close packing and the chemical nature of side chains. As shown, amphipathic α-helices having continuous hydrophobic stripes on their surfaces can be packed against each other in two main ways referred to here as face-to-face and side-by-side manners. Three types of the minimal hydrophobic stripes produced by the heptad (7-residue), undecatad (11-residue), and 4-residue repeats in the sequence have been analyzed and their role in packing of α-helices has been considered.

The role of lipid oxidation pathway in reactive oxygen species-mediated cargo release from liposomes.

Reactive oxygen species (ROS)-mediated photooxidation is an efficient method for triggering a drug release from liposomes. In addition to the release of small molecules, it also allows the release of large macromolecules, making it a versatile tool for controlled drug delivery. However, the exact release mechanism of large macromolecules from ROS-sensitive liposomes is still unclear.