Publications by authors named "A S David"
Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that plays an essential role during brain development. Using genetically engineered mouse model and primary neuronal cells, we identify the transcription factor E4F1 as a key coordinator of AcetylCoenzyme A (AcCoA) production by the pyruvate dehydrogenase complex (PDC) and its utilization as an essential co-factor by the Elongator complex to acetylate tRNAs at the wobble position uridine 34 (U).
View Article and Find Full Text PDFObjective: To describe postnatal outcome following the prenatal diagnosis of an abnormal fetal gallbladder.
Methods: We conducted a systematic review of studies from January 1980 to January 2023 that described FGB abnormalities, which included agenesis or non-visualisation, abnormal content presence of sludge, abnormal shape or size and abnormal position, and postnatal outcome to determine the association with pathology.
Results: In 51 studies, 842 fetuses had abnormal FGB.
Article Synopsis
- The LUX-ZEPLIN (LZ) experiment is a significant scientific study using a dual-phase xenon chamber located underground in South Dakota to search for dark matter interactions.
- The study extends existing theories to include relativistic effects, providing new constraints on the interactions between weakly interacting massive particles and nucleons based on their electric and magnetic dipole moments.
- Results include 90% confidence level limits on the coupling strength of five different interactions, analyzed over a specific energy range, which advances our understanding in particle physics beyond previous nonrelativistic effective field theories.