Publications by authors named "A S Cupp"
Article Synopsis
- Luteinizing hormone (LH) is key for ovulation and progesterone production across species but knowledge gaps remain about the metabolic processes involved.
- Research using metabolomics in luteal cells shows that LH rapidly activates pathways that increase glycolysis and oxygen use, stimulating lipid production.
- Discoveries highlight the importance of fatty acid synthesis and oxidation in progesterone production, suggesting potential approaches to improve ovarian function and create non-hormonal contraceptives.
The corpus luteum is a temporary endocrine gland that is crucial for pregnancy, as it produces the progesterone needed to maintain optimal uterine conditions for implantation. In the absence of a conceptus, the corpus luteum becomes non-functional and undergoes rapid tissue remodeling to regress into a fibrotic corpus albicans. Early luteal regression is characterized by increased cytokine release.
View Article and Find Full Text PDFOne of the hallmarks of invasive species is their propensity to spread. Removing an invasive species after establishment is virtually impossible, and so considerable effort is invested in preventing the range expansion of invaders. Silver carp (Hypophthalmichthys molitrix) were discovered in the Mississippi River in 1981 and have spread throughout the basin.
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- Pubertal attainment in heifers is essential for their reproductive longevity, with classifications identifying varying degrees of cyclicity: Early, Typical, Start-Stop (further divided into Start-Stop-Discontinuous and Start-Stop-Start), and Non-Cycling.
- Heritability of these classifications was assessed using genomic data from 532 heifers, showing moderate heritability (0.38) for all classifications and higher heritability (0.59) for those that initiated cyclicity versus those that did not.
- While a genome-wide association study (GWAS) did not pinpoint specific SNPs linked to pubertal classifications, an analysis of candidate genes revealed eight genes associated with pubertal classifications and twenty-two with
Steroidogenic tissues contain cytosolic lipid droplets that are important for steroidogenesis. Perilipin 2 (PLIN2), a structural coat protein located on the surface of lipid droplets in mammalian cells, plays a crucial role in regulating lipid droplet formation and contributing to various cellular processes such as lipid storage and energy homeostasis. Herein, we examine the role that PLIN2 plays in regulating progesterone synthesis in the bovine corpus luteum.
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