Publications by authors named "A S Chistov"

Enveloped viruses, such as flaviviruses and coronaviruses, are pathogens of significant medical concern that cause severe infections in humans. Some photosensitizers are known to possess virucidal activity against enveloped viruses, targeting their lipid bilayer. Here we report a series of halogenated difluoroboron-dipyrromethene (BODIPYs) photosensitizers with strong virus-inactivating activity.

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In this work, we conducted a study of the interaction between DNA and favipiravir (FAV). This chemotherapeutic compound is an antiviral drug for the treatment of COVID-19 and other infections caused by RNA viruses. This paper examines the electroanalytical characteristics of FAV.

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Article Synopsis
  • The study focuses on the molecular mechanism of gausemycins, which are a class of antibiotics, and details the isolation of new variants named gausemycins C, D, E, and F.
  • It was found that gausemycins A and B exhibit antimicrobial properties that depend on calcium concentrations, requiring more calcium than daptomycin but less than other antibiotics like malacidine.
  • The research confirmed that gausemycins affect bacterial membranes by forming pores, with the ability to do so influenced by the composition of the lipid membranes and calcium levels, as suggested by NMR studies on gausemycin B.
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Amphipathic perylene derivatives are broad-spectrum antivirals against enveloped viruses that act as fusion inhibitors in a light-dependent manner. The compounds target the lipid bilayer of the viral envelope using the lipophilic perylene moiety and photogenerating singlet oxygen, thereby causing damage to unsaturated lipids. Previous studies show that variation of the polar part of the molecule is important for antiviral activity.

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Azacarbazoles have attracted significant interest due to their valuable properties, such as anti-pathogenic and antitumor activity. In this study, a series of structurally related tricyclic benzo[4,5]- and tertacyclic naphtho[2',1':4,5]imidazo[1,2-c]pyrimidinone derivatives with one or two positively charged tethers were synthesized and evaluated for anti-proliferative activity. Lead tetracyclic derivative with two amino-bearing arms inhibited the metabolic activity of A549 lung adenocarcinoma cells with a CC value of 3.

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