Publications by authors named "A S Carew"

Background: During university life, students often face significant changes in relationships and academic pressures. Given the stressors faced by nursing students and the importance of their academic success, the study aimed to assess the impact of Super Brain Yoga on nursing students' concentration, memory, and academic progress.

Methods: This quasi-experimental study was conducted on 59 nursing students at Near East University in Cyprus from February to June 2023.

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  • In the ACCORD study, those with the haptoglobin 2-2 phenotype and high levels of glycated hemoglobin (HbA) showed a greater risk of coronary artery disease (CAD) compared to others with lower HbA levels, while this risk was not evident in those without the Hp2-2 phenotype.
  • The main goal was to see how different levels of HbA impact CAD risk among people with type 2 diabetes (T2DM) based on their haptoglobin phenotype, using data from the Look AHEAD study.
  • Results indicated that lower HbA levels (less than 6.5%) reduced CAD risk among non-Hp2-2 individuals, particularly in specific sub
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Background: Intensive glycemic control reduced the risk of coronary artery disease (CAD) events among White ACCORD study participants with the haptoglobin (Hp)2-2 phenotype, and not among participants without the Hp2-2 phenotype. It is unknown whether these results persist in a population with more severe diabetes.

Methods: Haptoglobin phenotype was measured in 1746 (97 %) samples from the Veterans Affairs Diabetes Trial (VADT) randomized controlled trial.

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  • Intensive glycemic control was found to reduce coronary artery disease (CAD) events in participants with the haptoglobin (Hp)2-2 phenotype in the ACCORD study, but not in those without this phenotype.
  • In the ADVANCE study, researchers evaluated the impact of intensive glycemic control on CAD risk, finding no significant benefits for participants with or without the Hp2-2 phenotype overall, but a notable risk reduction in Hp2-2 participants without prior cardiovascular disease.
  • The study concludes that intensive glycemic control may specifically help prevent major CAD events in individuals with the Hp2-2 phenotype who have no history of cardiovascular disease.
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  • Intensive lifestyle interventions (ILI) for weight loss and physical activity didn't significantly reduce coronary artery disease (CAD) events compared to standard education for participants with different haptoglobin (Hp) phenotypes in the Look AHEAD study.
  • The study found no significant differences in glycemic control (%HbA1c) between the ILI and diabetes support education (DSE) groups for either Hp phenotype.
  • Overall, the Hp phenotype did not affect the ILI's impact on CAD risk, suggesting that glycemic control wasn’t significantly influenced, and more research is necessary to confirm these findings.
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