Publications by authors named "A S Buchelnikov"
Article Synopsis
- - The text examines the aging and degradation of biological organisms through the lens of statistical physics, focusing on two key timescales: metabolic processes and life cycles.
- - It proposes a kinetic equation to explain short-term processes in these systems and emphasizes the need for a constant input of negative entropy to keep biological systems stable.
- - The study includes an analysis of epithelial aging and discusses the relationship between this approach and information theory, including the concept of cooperons and their evolution over time.
Article Synopsis
- The study explores how hemoglobin binds to oxygen, highlighting the cooperative nature of this process based on earlier works by Hill.
- The Adair model is noted for better fitting experimental data, though its parameter meanings are still not fully understood.
- The researchers improved upon Hill's approach by using a Lorentz distribution for oxygen partial pressure, resulting in a model that more accurately describes the experimental data than both the Hill and Adair equations.
There is a range of experimental proofs that biologically relevant compounds change their activity in the presence of C fullerene clusters in aqueous solution, which most frequently act as a nanoplatform for drug delivery. Inspired by this evidence, we made an effort to investigate the interaction of fullerene clusters with the antibiotic topotecan (TPT). This study proceeded in three steps, namely, UV/vis titration to confirm complexation and in vitro assays on proliferating and nonproliferating cells to elucidate the role of C fullerene in the putative change in TPT activity.
View Article and Find Full Text PDFWe performed a qualitative and quantitative analysis of intermolecular interactions in aqueous solution between the antitumor antibiotic mitoxantrone and C fullerene in comparison with interactions between the antibiotic and well-known aromatic molecules such as caffeine and flavin mononucleotide, commonly referred to as interceptor molecules. For these purposes, we obtained equilibrium hetero-association constants of these interactions using a UV/Vis titration experiment. Special attention was paid to the interaction of C fullerene with mitoxantrone, which has been quantified for the first time.
View Article and Find Full Text PDFArticle Synopsis
- * It highlights how cooperation among different parts of an organism reduces entropy, indicating that multicellular organisms have lower entropy compared to colonies of unicellular organisms.
- * A kinetic model of metabolism, aligning with Schrödinger's idea of "negentropy feeding," is introduced to calculate and compare local nonequilibrium entropy with equilibrium entropy found in non-living systems.