Publications by authors named "A S Browning"
Article Synopsis
- - Obstetric fistula is a serious childbirth injury that causes significant suffering for many women and girls, but it can often be treated successfully through surgical repair by trained surgeons.
- - Effective treatment involves not only surgery but also careful postoperative assessment to evaluate outcomes and address any ongoing issues, such as urinary retention or incontinence.
- - The article offers expert-approved recommendations for standardized protocols to assess surgical outcomes and manage follow-up care for patients after vesicovaginal fistula surgery.
Hyperpolarized (HP) C-labeled probes are emerging as promising agents to noninvasively image pH in vivo. HP [1,5-C]Z-OMPD (Z-4-methyl-2-oxopent-3-enedioic acid) in particular has recently been used to simultaneously report on kidney perfusion, filtration, and pH homeostasis, in addition to the ability to detect local tumor acidification. In previous studies, dissolution dynamic nuclear polarization was used to hyperpolarize Z-OMPD.
View Article and Find Full Text PDFBackground: During the dissolution of amorphous solid dispersion (ASD) formulations, the drug load (DL) often impacts the release mechanism and the occurrence of loss of release (LoR). The ASD/water interfacial gel layer and its specific phase behavior in connection with DL strongly dictate the release mechanism and LoR of ASDs, as reported in the literature. Thermodynamically driven liquid-liquid phase separation (LLPS) and/or drug crystallization at the interface are the key phase transformations that drive LoR.
View Article and Find Full Text PDFSignal Amplification by Reversible Exchange (SABRE) is a relatively simple and fast hyperpolarization technique that has been used to hyperpolarize the α-ketocarboxylate pyruvate, a central metabolite and the leading hyperpolarized MRI contrast agent. In this work, we show that SABRE can readily be extended to hyperpolarize C nuclei at natural abundance on many other α-ketocarboxylates. Hyperpolarization is observed and optimized on pyruvate (P=17 %) and 2-oxobutyrate (P=25 %) with alkyl chains in the R-group, oxaloacetate (P=11 %) and alpha-ketoglutarate (P=13 %) with carboxylate moieties in the R group, and phenylpyruvate (P=2 %) and phenylglyoxylate (P=2 %) with phenyl rings in the R-group.
View Article and Find Full Text PDFPurpose: Resilience, the ability to maintain or restore baseline function after a stressor, remains unexplored in patients with bladder cancer. Our objective was to demonstrate the feasibility of prospectively characterizing baseline resilience, related psychological resources, and frailty in patients with bladder cancer and evaluate associations with quality-of-life and mental health outcomes over time.
Materials And Methods: We enrolled patients with bladder cancer (N = 67, September 2020-July 2021) into a prospective, observational, cohort study.