Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis.

Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, parasites internalize and digest abundant host hemoglobin within the digestive vacuole. This massive catabolic process generates copious free heme, most of which is biomineralized into inert hemozoin.

Harnessing hope and bolstering knowledge of how to quit: a qualitative investigation of including efficacy content in tobacco risk communication via daily SMS.

Introduction: Tobacco warning labels typically feature confronting health risk messages which aim to evoke fear to change behaviour. Evidence shows these graphic health warning labels (GHWLs) can be effective but can also lead to unintended responses, including avoidance or defensiveness. Theory suggests that targeting beliefs about the likelihood and benefits of successfully quitting may increase adaptive responses to risk information.

Overcoming Compassion Fatigue and Burnout in Pediatric Oncology Nurses: Implementation of a Staff Well-Being Program.

As frontline healthcare workers, pediatric oncology nurses are at high risk for burnout, compassion fatigue, and decreased compassion satisfaction. Research indicates that up to 60% of oncology staff experience some form of burnout. This can lead to difficulties in personal and professional relationships, decreased staff retention, and negative effects on patient safety.

Biogenesis of Cytochromes and in the Electron Transport Chain of Malaria Parasites.

malaria parasites retain an essential mitochondrional electron transport chain (ETC) that is critical for growth within humans and mosquitoes and is a key antimalarial drug target. ETC function requires cytochromes and , which are unusual among heme proteins due to their covalent binding to heme via conserved CXXCH sequence motifs. Heme attachment to these proteins in most eukaryotes requires the mitochondrial enzyme holocytochrome synthase (HCCS) that binds heme and the apo cytochrome to facilitate the biogenesis of the mature cytochrome or .