Biocompatibility and customizability: Expanding possibilities with 3D printed guide cannulas.

Background: Intracerebral cannulation bypasses the blood-brain barrier, and is frequently used for targeted drug delivery to specific brain structures. Despite the availability of brain infusion kits and manual injections without cannulation, the traditional design of guide cannulas continues to be utilized in research. Several protocols describing guide cannula manufacture from stainless steel needles have been published previously.

[A preclinical evaluation of the pharmacological activity of a mixed potassium and magnesium glutamate].

Mixed magnesium and potassium glutamates with different ion ratio are synthesized. The antiarrhythmic activity of the compounds obtained is studied on the models of strophantin, calcium chloride, aconitine arrhythmia, and arrhythmia after Harriss. It is found that magnesium and potassium glutamate of the composition KMg(HGlu)4.

[The main stages in the pharmacokinetic research on new substances].

The main stages in studying pharmacokinetics of new drugs are discussed. They include: development of a micromethod for determining drugs in biological objects, estimation of drug stability in biological objects on storage, evaluation of drug distribution coefficients, investigation of drug solubility rate, drug binding to plasma proteins and erythrocytes, studying of drug metabolism in vitro and in vivo, investigation of drug kinetics in test tissues after single and repeated administrations, estimation of drug bioavailability, investigation of drug excretion and distribution in organs and tissues, determination of concentration-effect relationships in test tissues and studying of drug pharmacokinetics in models simulating pathological processes.

[Clinical pharmacokinetics of mebikar. Computation of individual dosage regimens].

The authors review the principles of calculating the optimal dosage regimens of mebicar used in the treatment of borderline psychopathological abnormalities in alcoholics. Mebicar administered to patients according to the calculated dosage regimens ensures the positive clinical effect. This is supported by the clinicopsychopathological and electrophysiological data.

[Clinical pharmacokinetics of mebikar].

Twenty-two patients admitted to the narcological clinic of an industrial enterprise were examined for the clinical effect and pharmacokinetic parameters after intake of a single dose of a Soviet psychotropic drug mebicar. The clinical status was assessed by means of psychometric mapping and concurrent recording of the EEG. The correlation of the pharmacodynamic and pharmacokinetic data can be used for the choice of minimal effective concentrations applied in further calculations of individual dosage regimens.