Intra- and interobserver agreement in evaluation of image-defined risk factors on computed tomography in pediatric neuroblastoma.

Background: Image-defined risk factors (IDRFs) were introduced to provide a consensus approach for pre-treatment risk stratification on computed tomography (CT) and magnetic resonance imaging (MRI) in patients with neuroblastoma.

Objective: To assess the intra- and inter-reader agreement of radiologists in identifying IDRFs on CT.

Materials And Methods: Approval for this retrospective study was granted by our institutional research ethics board with a waiver of consent.

The Challenge of Diagnosing Acute Myeloid Leukemia or Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report.

Background/aim: Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and highly aggressive hematologic cancer which is difficult to diagnose and has a lot of overlapping features with other diseases, particularly acute myeloid leukemia (AML). BPDCN shares several immunophenotypic markers with AML, such as CD4, CD56, CD123, and HLA-DR, stating the importance of having extending panel of specific immunohistochemical (IHC) markers.

Case Report: This report details a case of CLL who presented with worsening symptoms of recurrent infections and leukocytosis.

The role of visfatin in peripheral immune organs and intestines of weaned piglets under lipopolysaccharide induced immune stress.

To investigate the regulatory mechanisms and pathways of visfatin under immune stress injury in weaned piglets, we established a lipopolysaccharide-induced immune stress model in weaned piglets to study how visfatin affects peripheral immune organs and intestinal function. The results revealed that visfatin improved the inflammatory response in immune-stressed weaned piglets by reducing the levels of pro-inflammatory cytokines interleukin-1β, interleukin-6 and monocyte chemoattractant protein-1, as well as decreasing the neutrophil/lymphocyte ratio. Visfatin ameliorated oxidative stress in piglets by promoting the expression of superoxide dismutase and glutathione peroxidase.

Viral-host molecular interactions and metabolic modulation: Strategies to inhibit flaviviruses pathogenesis.

Flaviviruses, which include globally impactful pathogens, such as West Nile virus, yellow fever virus, Zika virus, Japanese encephalitis virus, and dengue virus, contribute significantly to human infections. Despite the ongoing emergence and resurgence of flavivirus-mediated pathogenesis, the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral infections. Through the intricate processes of fusion, transcription, replication, and maturation, the complex interplay of viral and host metabolic interactions affects pathophysiology.

Robustness assessment of Muscat coastal highway network (CHN) under multi-hazard scenarios focusing on traffic stability and adaptation measures.

This study critically examines the reliability and resilience of the Muscat coastal highway network (CHN) under the compounded effects of earthquakes and floods, representing interacting multi-hazard scenarios. The analysis utilized fragility functions for both earthquake-induced and flood-induced landslides, integrating these with traffic data for selected highway links to estimate bridge damage and assess CHN functionality in post-hazard conditions. Economic sensitivity analysis revealed a significant increase in costs due to flood-induced landslides, emphasizing the impact of dominant intensity measures on network costs and traffic flow.