Publications by authors named "A S Annapurna"
Polyphenols are natural biomolecules known for circumventing several diseases including cancer with little adverse effects. This study aimed to investigate the polyphenol enriched fractions from the leaf extract of Asystasia gangetica for their composition, biological activities such as antioxidant activity, haemolytic effects, and in vitro cytotoxicity against cancer cell lines. LC-MS/MS analysis of the enriched fractions identified a total of 35 distinct polyphenols with caffeic acid, luteolin, apigenin, and protocatechuic acid at higher concentrations.
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- The study aims to assess the protective effects of wheatgrass and Bauhinia flower powders against brain damage caused by ischemia-reperfusion injury in rats.
- The research involved administering different doses of these powders before inducing the injury and found that both powders significantly reduced brain damage in a dose-dependent manner.
- Results indicated that wheatgrass and Bauhinia powders increased antioxidant enzyme levels and decreased lipid peroxidation, suggesting their potential use in Ayurvedic medicine for treating cerebral ischemia-related conditions.*
Correlation of various serum biomarkers with the severity of diabetic retinopathy.
Diabetes Metab Syndr
November 2017
Unlabelled: Hyperglycemia induced inflammation and angiogenic factors are implicated as a contributor to the onset and progression of diabetic retinopathy (DR) in type 2 diabetes mellitus patients (T2DM). Tumor necrosis factor (TNF-alpha) and C-reactive protein (CRP) are inflammatory cytokines which induce retinal VEGF and are involved in the progression of proliferative diabetic retinopathy (PDR). Therefore the aim of the present study is to investigate the relationship between diabetic retinopathy and systemic inflammation in patients with type 2 diabetes mellitus.
View Article and Find Full Text PDFThe study was conducted to evaluate the vanadium-induced testicular toxicity and its effect on sperm parameters, sperm nuclear DNA damage and histological alterations in Sprague Dawley rats and to assess the protective effect of G-hesperidin against this damage. Treatment of rats with vanadium at a dose of 1 mg kg bw(-1) for 90 days resulted in significant reduction in serum testosterone levels, sperm count and motility. Further, a parallel increase in abnormal sperm morphology and adverse histopathological changes in testis was also associated with vanadium administration when compared to normal control.
View Article and Find Full Text PDFBackground: There is a comprehensive body of experimental and clinical evidence suggesting that exogenous supplementation of natural antioxidants or augmentation of endogenous antioxidants attenuates the damage caused by myocardial infarction.
Objective: To evaluate the cardioprotective effects of Cl-chalcone and F-chalcone against ischemia/reperfusion (I/R)-induced myocardial infarction in rats.
Methods: Myocardial infarct size was measured using the staining agent 2,3,5-triphenyltetrazolium chloride.