Unsupervised learning to identify symptom clusters in older adults undergoing chemotherapy.

Introduction: Unsupervised machine learning (ML) approaches such as clustering have not been commonly applied to patient-reported data. This study describes ML methods to explore and describe patient-reported symptom trajectories in older adults receiving chemotherapy.

Materials And Methods: This secondary analysis of prospectively collected data from the GAP 70+ Trial (NCT02054741; PI: Mohile) collected patient-reported symptoms at baseline (pre-chemotherapy), six weeks, three months, and six months.

Molecular insights from 2023 and 2024 outbreaks reveal exclusive circulation of peste des petits ruminants virus lineage IV in India.

Peste des petits ruminants (PPR) is a highly contagious disease affecting sheep and goats, caused by PPR virus (PPRV), a member of the genus Morbillivirus. In 2023 and 2024, on testing of suspected clinical samples for PPR received through passive surveillance of sheep and goat flocks in various states of India resulted in the documentation of 15 laboratory-confirmed outbreaks of PPR. During the outbreak investigation, morbidity and significant mortality rates were observed, and clinical samples collected from the affected flocks were tested using ELISA and RT-PCR, confirming the presence of PPRV.

Understanding hospital activity and outcomes for people with multimorbidity using electronic health records.

As the prevalence of multimorbidity grows, provision of effective healthcare is more challenging. Both multimorbidity and complexity in healthcare delivery may be associated with worse outcomes. We studied consecutive, unique emergency non-surgical hospitalisations for patients over 50 years old to three hospitals in Scotland, UK between 2016 and 2024 using linked primary care and hospital records to define multimorbidity (2 + long-term conditions), and timestamped hospital electronic health record (EHR) contacts with nursing and rehabilitation providers to describe intensity of inpatient care.

Atypical Head and Neck Cysticercosis: Diagnostic Pitfalls and Clinical Insights from a Case Series and Literature Review.

Head and neck swellings encompass a broad range of differential diagnoses, often necessitating comprehensive clinical and diagnostic evaluations to reach an accurate diagnosis. Cysticercosis, a parasitic infection caused by the larval form of Taenia solium, typically affects neural and extraneural regions. Although neural manifestations are well-documented, extraneural cysticercosis in the head and neck is rare and can mimic neoplastic and inflammatory conditions, posing diagnostic challenges.