Publications by authors named "A S Alia"
Article Synopsis
- ACE1 plays a crucial role in regulating blood pressure and is important for cognitive functions like learning and memory, primarily expressed in the excitatory neurons of the hippocampus.
- Research conducted with ACE1 conditional knockout (cKO) mice revealed significant memory impairments and dysregulation of the renin-angiotensin system in the hippocampus, even when total ACE1 levels were reduced in both hippocampus and cortex.
- The findings highlight a specific vulnerability in the hippocampal microvasculature and suggest a connection between neuronal ACE1 and cerebrovascular health in that region of the brain.
Photosynthetic reaction centers (RCs) serve as natural engines converting solar energy to chemical energy. Understanding the principles of efficient charge separation and light-induced electron transfer (ET) between the chlorophyll-type pigments might guide the synthesis for artificial photosynthetic systems. We present detailed insight into the dynamics at the atomic level using solid-state NMR techniques applied to the RCs of (HbRCs) and the purple bacterium (PbRCs).
View Article and Find Full Text PDFThe third Asia Pacific Drosophila Neurobiology Conference (APDNC3) was held in the Wako Campus of RIKEN in Tokyo, Japan, from February 27th to March 1st, 2024. While APDNC2 was held in Taiwan in 2019, the global coronavirus pandemic enforced a long hiatus. Hence, APDNC3 was a much-anticipated meeting that attracted ~218 scientists from 18 different countries and regions, 154 from outside Japan.
View Article and Find Full Text PDFArticle Synopsis
- T-2 toxin, a highly toxic trichothecene mycotoxin, was studied using high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR) and zebrafish embryos to explore its toxicity mechanisms.
- The study found that T-2 exposure resulted in lethality at around 105 ppb and influenced the production of reactive oxygen species (ROS), causing varied ROS levels in different organs.
- Metabolic profiling indicated significant disturbances in detoxification processes, membrane phospholipids, mitochondrial energy metabolism, and glucose metabolism, leading to a comprehensive understanding of T-2 toxicity for health implications.
Article Synopsis
- Zebrafish serve as a key model for studying neurodegenerative diseases, but achieving cellular resolution in their brain imaging has been difficult.
- The study presents groundbreaking MRI results at a high magnetic field strength of 28.2 T, achieving a 20% better signal-to-noise ratio compared to the previous 17.6 T, allowing for clearer brain structure visualization.
- Advanced imaging techniques like diffusion tensor imaging (DTI) and constrained spherical deconvolution are used to non-invasively identify white matter structures with high resolution, paving the way for better understanding of microstructural changes in zebrafish models of brain diseases.