Cardiotoxic Effects Following CAR-T Cell Therapy: A Literature Review.

Purpose Of Review: This paper reviewed the current literature on incidence, clinical manifestations, and risk factors of Chimeric Antigen Receptor T-cell (CAR-T) cardiotoxicity.

Recent Findings: CAR-T therapy has emerged as a groundbreaking treatment for hematological malignancies since FDA approval in 2017. CAR-T therapy is however associated with a few side effects, among which cardiotoxicity is of significant concern.

A Unified Approach to Health Data Exchange: A Report From the US DHHS.

Importance: Health information technology, such as electronic health records (EHRs), has been widely adopted, yet accessing and exchanging data in the fragmented US health care system remains challenging. To unlock the potential of EHR data to improve patient health, public health, and health care, it is essential to streamline the exchange of health data. As leaders across the US Department of Health and Human Services (DHHS), we describe how DHHS has implemented fundamental building blocks to achieve this vision.

Cone-Beam Computed Tomography Evaluation of the Mandibular Condyle and Articular Spaces Following Orthognathic Surgery Using Freehand Articulation Method in Patients With Class II and III Skeletal Deformity.

This study aimed to assess the changes in the position and size of articular spaces and anteroposterior and mediolateral condyle dimensions following orthognathic surgery. Additionally, it evaluated the correlation between these changes and mandibular movement during surgery. This experimental study examined 31 patients (16 with Class III and 15 with Class II malocclusions) who were candidates for orthognathic surgery.

Genome-wide association study (GWAS) uncovers candidate genes linked to the germination performance of bread wheat (Triticum aestivum L.) under salt stress.

Background: Improving the germination performance of bread wheat is an important breeding target in many wheat-growing countries where seedlings are often established in soils with high salinity levels. This study sought to characterize the molecular mechanisms underlying germination performance in salt-stressed wheat. To achieve this goal, a genome-wide association study (GWAS) was performed on 292 Iranian bread wheat accessions, including 202 landraces and 90 cultivars.