Publications by authors named "A Ryung Nam"
Article Synopsis
- The study identified cytotoxic compounds, falcarinol and falcarindiol, from the roots of Glehnia littoralis, effective against both sensitive and resistant colorectal and lung cancer cells.
- Researchers isolated 13 polyacetylenes, including a new compound (3R,11R)-11-hyroxy-isofalcarinolone, using advanced chemical analysis techniques.
- Findings suggest that while these compounds show potential for anticancer development, their stability needs further investigation since some newly purified compounds did not exhibit expected activity.
An analytical method for nine tranquilizer compounds, including eight major natural oil components and 2-phenoxyethanol, was developed using gas chromatography tandem mass spectrometry and validated under CODEX and National Institute of Food and Drug Safety Evaluation guidelines. Subsequently, 315 live seafood samples under Korean preference for sashimi (eight species) were monitored with sales distribution channels and place of origin. A total of 76 detection cases in 65 seafood samples contained the target tranquilizer compounds at concentrations ranging from 2.
View Article and Find Full Text PDFImportance: Central nervous system (CNS) metastases presenting as either brain parenchymal metastases or leptomeningeal metastases are diagnosed in up to 50% of patients with advanced non-small cell lung cancer during their disease course. While historically associated with a poor prognosis due to limited treatment options, the availability of an increasing number of targeted therapies with good CNS penetration has significantly improved clinical outcomes for these patients. This has occurred in parallel with a more nuanced understanding of prognostic factors.
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- * This study explores the anticancer effects of deoxybouvardin glucoside (DBG) on both gefitinib-sensitive and -resistant NSCLC cells, revealing that DBG inhibits cell growth and targets key protein kinases like EGFR, MET, and AKT.
- * DBG treatment also causes an increase in reactive oxygen species (ROS) and triggers apoptosis through caspase activation, indicating its potential as a new therapeutic option for treating gefitinib-resistant NSCLC.
Lymphoma is one of the most common malignant tumors in dogs. Combination chemotherapy with vincristine, cyclophosphamide, doxorubicin, and prednisolone (CHOP) is the most effective treatment for multicentric lymphoma. Previous studies have evaluated the response of large dogs to CHOP treatment and identified prognostic factors; however, studies on small dogs are lacking.
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