Publications by authors named "A Rupani"
Background: Drug-resistant tuberculosis (DR-TB) significantly increases the risk of depression, yet research on mental health in this population remains limited.
Aim: This meta-analysis aimed to evaluate the prevalence of depression among multidrug-resistant TB (MDR-TB) patients, emphasizing the necessity for integrated mental health care.
Methods: A systematic search across PubMed, Cochrane, EBSCOhost, and Google Scholar identified 536 articles, which were screened for eligibility after removing duplicates.
Introduction: Surgical research has revolutionized healthcare by improving the efficacy, safety, and efficiency of surgical interventions. This research has the potential to significantly impact healthcare delivery in Africa, where surgical diseases pose a major public health burden. Studies suggest surgery alone could reduce the global disease burden by 11%, with a substantial portion stemming from conditions prevalent in sub-Saharan Africa like traumatic injuries, childbirth complications, and surgical infections.
View Article and Find Full Text PDFArticle Synopsis
- Superficial malignant peripheral nerve sheath tumors (SF-MPNSTs) are rare cancers that share some features with spindle cell melanomas and desmoplastic melanomas, but their biological characteristics remain poorly understood.* -
- A study comparing SF-MPNST to other tumor types through whole-exome and RNA sequencing found that SF-MPNST had an intermediate tumor mutational burden and distinct gene expression patterns, indicating differences among these cancer types.* -
- Immunohistochemical analysis revealed notable differences in markers like H3K27me3 and PRAME between SF-MPNST and other cancers, suggesting potential for new diagnostic markers and insights into tumor behavior.*
Rationale: Despite the prioritizing the healthcare workers (HCWs) for COVID-19 in a systematized manner the phenomenon of vaccine hesitancy was observed in them. HCWs are presumed to be pre-emptive in up-taking the vaccine due to their closest association and having reasonable background information. Hence, we intended to explore and investigate the phenomenology of skepticism and hesitancy toward the COVID-19 vaccine among HCWs.
View Article and Find Full Text PDFImmune checkpoint blockade is a promising approach to activate antitumor immunity and improve the survival of patients with cancer. V-domain immunoglobulin suppressor of T cell activation (VISTA) is an immune checkpoint target; however, the downstream signaling mechanisms are elusive. Here, we identify leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) as a VISTA binding partner, which acts as an inhibitory receptor by engaging VISTA and suppressing T cell receptor signaling pathways.
View Article and Find Full Text PDF