Publications by authors named "A Ruiz-Sanmartin"
Article Synopsis
- - The text discusses the need to identify specific subgroups of sepsis patients who might benefit from targeted treatments, known as rescue therapies, even while all patients receive standard care.
- - It highlights the classification of sepsis into various phenotypes, which are based on differing immune responses, such as hyperinflammatory or immunosuppressive states, suggesting that each may require tailored therapies for better outcomes.
- - The concept of precision medicine is emphasized, aiming to customize treatments according to the unique characteristics and mechanisms of sepsis in individual patients, focusing on developing targeted interventions.
Article Synopsis
- Streptococcal toxic shock syndrome (STTS) is a severe medical emergency characterized by rapid symptom onset and high risks of morbidity and mortality, highlighting the need for quick recognition and intervention.
- A study observed 13 patients at Vall d'Hebron University Hospital with invasive infections, primarily community-acquired pneumonia and skin infections, all receiving immediate antibiotic treatment and various organ support therapies.
- The research identified three patient phenotypes (hyperinflammatory, low perfusion, hypogammaglobulinemic) that could help tailor personalized treatments, stressing the importance of combining rapid antibiotics and strategic source control to improve survival outcomes.
Objectives: To determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.
Design: Prospective, observational, single-center study.
Setting: Intensive Care Unit (ICU), Vall d'Hebron University Hospital, Barcelona.
In COVID-19, hyperinflammatory and dysregulated immune responses contribute to severity. Patients with pre-existing autoimmune conditions can therefore be at increased risk of severe COVID-19 and/or associated sequelae, yet SARS-CoV-2 infection in this group has been little studied. Here, we performed single-cell analysis of peripheral blood mononuclear cells from patients with three major autoimmune diseases (rheumatoid arthritis, psoriasis, or multiple sclerosis) during SARS-CoV-2 infection.
View Article and Find Full Text PDFEarly diagnosis and appropriate treatments are crucial to reducing mortality risk in septic patients. Low SOFA scores and current biomarkers may not adequately discern patients that could develop severe organ dysfunction or have an elevated mortality risk. The aim of this prospective observational study was to evaluate the predictive value of the biomarkers mid-regional pro-adrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate for 28-day mortality in patients with sepsis, and patients with a SOFA score ≤6.
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