Publications by authors named "A Ruef"
Symptom heterogeneity characterizes psychotic disorders and hinders the delineation of underlying biomarkers. Here, we identify symptom-based subtypes of recent-onset psychosis (ROP) patients from the multi-center PRONIA (Personalized Prognostic Tools for Early Psychosis Management) database and explore their multimodal biological and functional signatures. We clustered N = 328 ROP patients based on their maximum factor scores in an exploratory factor analysis on the items.
View Article and Find Full Text PDFAlterations of Functional Connectivity Dynamics in Affective and Psychotic Disorders.
Biol Psychiatry Cogn Neurosci Neuroimaging
August 2024
Background: Patients with psychosis and patients with depression exhibit widespread neurobiological abnormalities. The analysis of dynamic functional connectivity (dFC) allows for the detection of changes in complex brain activity patterns, providing insights into common and unique processes underlying these disorders.
Methods: We report the analysis of dFC in a large sample including 127 patients at clinical high risk for psychosis, 142 patients with recent-onset psychosis, 134 patients with recent-onset depression, and 256 healthy control participants.
Cognitively impaired and spared patient subgroups were identified in psychosis and depression, and in clinical high-risk for psychosis (CHR). Studies suggest differences in underlying brain structural and functional characteristics. It is unclear whether cognitive subgroups are transdiagnostic phenomena in early stages of psychotic and affective disorder which can be validated on the neural level.
View Article and Find Full Text PDFA multivariate cognitive approach to predict social functioning in recent onset psychosis in response to computerized cognitive training.
Prog Neuropsychopharmacol Biol Psychiatry
January 2024
Article Synopsis
- Scientists are using clinical and brain scan data to understand how treatment helps people with early psychosis improve their thinking and social skills.
- They found that cognitive training (CT) can slightly improve these skills for patients with early psychosis, and they used a special computer program to predict who would benefit the most from CT.
- By analyzing data from a European study, they determined that they could correctly predict social improvement for around 66% of these patients based on their initial cognitive skills.
Structural and Functional Brain Patterns Predict Formal Thought Disorder's Severity and Its Persistence in Recent-Onset Psychosis: Results From the PRONIA Study.
Biol Psychiatry Cogn Neurosci Neuroimaging
December 2023
Background: Formal thought disorder (FThD) is a core feature of psychosis, and its severity and long-term persistence relates to poor clinical outcomes. However, advances in developing early recognition and management tools for FThD are hindered by a lack of insight into the brain-level predictors of FThD states and progression at the individual level.
Methods: Two hundred thirty-three individuals with recent-onset psychosis were drawn from the multisite European Prognostic Tools for Early Psychosis Management study.