Publications by authors named "A Rozy"
Article Synopsis
- Severe inherited alpha-1 antitrypsin deficiency (AATD) is linked to chronic obstructive pulmonary disease (COPD), but the impact of milder deficiency variants in children is unclear.
- A study of 145 children with varying wheezing severity revealed a higher prevalence of the Pi*Z allele in wheezers compared to a control group; however, there was no connection between AAT genotypes and the severity of wheezing.
- These findings suggest that specific AATD genotypes in children may indicate a genetic link to future COPD, highlighting the need for further research with larger groups.
Introduction: Compared to normal PiMM, individuals with severe α1-antitrypsin (AAT) PiZZ (Glu342Lys) genotype deficiency are at higher risk of developing early-onset chronic obstructive pulmonary disease (COPD)/emphysema associated with Z-AAT polymers and neutrophilic inflammation. We aimed to investigate putative differences in plasma levels of acute phase proteins (APP) between PiMM and PiZZ subjects and to determine plasma Z-AAT polymer levels in PiZZ subjects.
Materials And Methods: Nephelometric analysis of seven plasma APPs was performed in 67 PiMM and 44 PiZZ subjects, of whom 43 and 42, respectively, had stable COPD.
Hypersensitivity pneumonitis (HP) is an exposure-related interstitial lung disease with two phenotypes-fibrotic and non-fibrotic. Genetic predisposition is an important factor in the disease pathogenesis and fibrosis development. Several genes are supposed to be associated with the fibrosing cascade in the lungs.
View Article and Find Full Text PDFBackground: Fibrotic hypersensitivity pneumonitis (fHP) shares many features with other fibrotic interstitial lung diseases (ILD), and as a result it can be misdiagnosed as idiopathic pulmonary fibrosis (IPF). We aimed to determine the value of bronchoalveolar lavage (BAL) total cell count (TCC) and lymphocytosis in distinguishing fHP and IPF and to evaluate the best cut-off points discriminating these two fibrotic ILD.
Methods: A retrospective cohort study of fHP and IPF patients diagnosed between 2005 and 2018 was conducted.
Background: SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently, various markers reflect this wide spectrum of disease presentations.
Methods: Our pilot cohort included moderate (n = 10) and severe (n = 10) COVID-19 patients, and 10 healthy controls.