Publications by authors named "A Rozieres"
Crohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic functional status of autophagy.
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- Data on the long-term effects of drug exposure during pregnancy on childhood development is limited and varies based on exposure duration and maternal drug levels.
- Therapeutic drug monitoring during pregnancy can help manage drug exposure in mothers with inflammatory bowel disease (IBD) while ensuring effective treatment.
- Anti-TNFα therapies, like adalimumab (ADA) and infliximab (IFX), have been found relatively safe during pregnancy, with low concentrations in breast milk, allowing for continued breastfeeding; however, more research is needed on other drugs like ustekinumab and vedolizumab.
Background And Aims: Tofacitinib (TFB) appears to be effective in the treatment of ulcerative colitis (UC); however, available real-world studies are limited by cohort size. TFB could be an option in the treatment of acute severe ulcerative colitis (ASUC). We aimed to investigate efficacy and safety of TFB in moderate-to-severe colitis and ASUC.
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