[Demyelinating disease in human immunodeficiency virus-infected patients without severe immunodepression].

Objective: Human immunodeficiency virus (HIV) infected patients who did not have severe immunodepression were analysed for multiple demyelinating lesions.

Methods: Patients with a CD4 greater than 200/μL were selected after a search was made in a computerised data base.

Results: Four patients were found, three were co-infected with hepatitis C virus (HCV), with one of them on treatment with peg-interferón α-2b and ribavirin.

Ictus and antiphospholipid syndrome: how much is enough?

Herein we report the case of a patient with antiphospholipid Syndrome (APS) and an ischemic stroke suffered while he was anticoagulated, and we discuss the usefulness of magnetic resonance angiography in the early diagnosis of such a complication. We also attempt to emphasize the great value of an individual risk evaluation when warfarin therapy is introduced. In fact, our case supports the importance of high-intensity anticoagulation in patients with multiple thrombotic recurrences, and the exceptional value that strict anticoagulation control has in this kind of patients.

[Atrophy of the cervical spinal cord as a consequence of a prenatal ischemic infarct].

Introduction: Spinal cord injuries in newborn infants following a traumatic delivery are well known, but occasionally cord damage is appreciated in children whose birth did not involve any complications; in some of them there has been proof of an ischemic process that originated inside the uterus.

Case Report: We describe the case of a newborn female with atrophy of the cervical spinal cord compatible with an intrauterine ischemic infarct. It extended to the C4-C6 territory of the anterior spinal artery, with greater participation on the left side.

[Interferon alpha and infantile orbital hemangioma].

Objective: To determine the efficacy and safety of interferon alpha therapy for the treatment of infantile periorbital hemangiomas associated with visual impairment.

Methods: Retrospective study of 4 patients diagnosed of orbital hemangioma during infancy. All of them were treated with interferon alpha 2b at doses of 3 million U/m2, administered once daily by subcutaneous injection, at least during 3.