Publications by authors named "A Rotenberg"
Article Synopsis
- In drug-resistant epilepsy, the study focuses on using deep learning to analyze intracranial electroencephalography (iEEG) signals, specifically through time-frequency (TF) images, to locate the epileptogenic zone (EZ) for surgical guidance.
- The researchers processed iEEG data from 20 children and employed a pre-trained neural network (VGG16) to measure visual complexity, revealing that contacts within the seizure onset zone had significantly lower activation energy compared to those outside.
- The findings suggest a new computer-assisted method for accurately localizing the EZ with a 7 mm accuracy in MRI scans, potentially reducing the need for extensive manual iEEG examinations.
Introduction: To assess the alpha-delta ratio (ADR) as a biomarker for cerebral injury and stroke in pediatric extracorporeal membrane oxygenation (ECMO).
Methods: Retrospective study of children aged >44 weeks gestation to 21 years monitored with continuous electroencephalography during ECMO. The interhemispheric ADR difference between the left and right hemisphere was calculated per hour.
Objective: Excitotoxicity is a common hallmark of epilepsy and other neurological diseases associated with elevated extracellular glutamate levels. Thus, here, we studied the protective effects of (R)-AS-1, a positive allosteric modulator (PAM) of glutamate uptake in epilepsy models.
Methods: (R)-AS-1 was evaluated in a range of acute and chronic seizure models, while its adverse effect profile was assessed in a panel of standard tests in rodents.
Article Synopsis
- * An 18-year-old male with drug-resistant epilepsy underwent laser interstitial thermotherapy (LiTT) for a lesion in the left PCC, leading to temporary symptoms like spatial neglect and sensory loss, while also being seizure-free for over 10 months post-surgery.
- * This case highlights the need to consider individual brain variations and atypical surgical outcomes in epilepsy treatment, emphasizing the importance of understanding brain connectivity and handedness, especially in younger patients.
Parvalbumin-positive (PV+) basket neurons are fast-spiking, non-adapting inhibitory interneurons whose oscillatory activity is essential for regulating cortical excitation/inhibition balance. Their dysfunction results in cortical hyperexcitability and gamma rhythm disruption, which have recently gained substantial traction as contributing factors as well as potential therapeutic targets for the treatment of Alzheimer's Disease (AD). Recent evidence indicates that PV+ cells are also impaired in Frontotemporal Dementia (FTD) and Dementia with Lewy bodies (DLB).
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