Publications by authors named "A Roszak"
The article aims to outline the potential of treating malignant skin cancer with microneedles covered with polymer layers containing a photosensitizer-protoporphyrin IX disodium salt (PPIX). The usefulness of stereolithography (SLA), which is a form of 3D-printing technology, for the preparation of a microneedle system with protoporphyrin IX was demonstrated. The SLA method allowed for pyramid-shaped microneedles to be printed that were covered with three different 0.
View Article and Find Full Text PDFPrevious studies have demonstrated an association of the NC_000012.12:g.53962605A > G, (rs2366152) single-nucleotide variant (SNV) situated in the long noncoding homeobox transcript antisense intergenic RNA (HOTAIR) gene with HPV16-related cervical cancer pathogenesis.
View Article and Find Full Text PDFArticle Synopsis
- Mirvetuximab soravtansine-gynx (MIRV) is an antibody-drug conjugate approved in the U.S. for treating platinum-resistant ovarian cancer, showing promise in a recent phase 3 trial comparing it to standard chemotherapy.
- The study involved 453 participants with high FRα expression, demonstrating that those treated with MIRV had a median progression-free survival of 5.62 months, significantly longer than the 3.98 months for those on chemotherapy.
- Additionally, MIRV led to higher objective response rates (42.3% vs. 15.9%) and longer overall survival (16.46 months vs. 12.75 months), while also resulting in fewer severe
The objective of this study was to assess the prognostic value of asphericity (ASP) and standardized uptake ratio (SUR) in cervical cancer patients. Retrospective analysis was performed on a group of 508 (aged 55 ± 12 years) previously untreated cervical cancer patients. All patients underwent a pretreatment [F]FDG PET/CT study to assess the severity of the disease.
View Article and Find Full Text PDFSuperficial high-dose-rate brachytherapy for primary tumors and relapses after surgery in patients with basal cell carcinoma of the head and neck region: results of a retrospective comparative cohort study.
J Contemp Brachytherapy
October 2022
Purpose: The recommended treatments for basal cell carcinoma (BCC) in the head and neck (H&N) region are Mohs surgery, standard surgical excision (SSE), and radiotherapy. According to the literature, local recurrence after surgical treatment in this area is associated with a worse prognosis in case of re-treatment. To our knowledge, there are no reports on high-dose-rate brachytherapy (HDR-BT) for BCC of the H&N region, both in primary lesions and relapses after SSE.
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