Publications by authors named "A Rosenbloom"
Background And Objective: Local intraprostatic radiorecurrence of prostate cancer (IPR-PC) can be associated with an aggressive natural history and impact long-term disease-specific survival. While appropriate local salvage intervention can be curative, best practices for workup and local salvage of intraprostatic recurrence are poorly defined. The American Radium Society (ARS) Genitourinary Appropriate Use Criteria Committee sought to develop evidence-based recommendations to address this gap.
View Article and Find Full Text PDFTexas has a tremendous opportunity and momentum to build a more effective system of care for children with medical complexity (CMC) and their families. This is evidenced by growing collaboration among many committed partners since implementation of the Medicaid STAR Kids managed care program in 2016 and Texas' participation in a US Health Resources and Services Administration-funded, 10-state Collaborative Improvement and Innovation Network to Advance Care for CMC from 2017 to 2022. Texas has several comprehensive health homes for CMC that position the state to serve as a national model of integrated, family-centered care for CMC and ensure high-quality care to an exceedingly vulnerable population.
View Article and Find Full Text PDFArticle Synopsis
- - This study introduces a new spatial proteogenomic (SPG) assay on the GeoMx Digital Spatial Profiler platform, which allows for high-plex analysis of proteins (>100) and RNA (>18,000) from a single tissue sample.
- - The SPG assay shows high accuracy and reproducibility in analyzing human and mouse tissues, effectively distinguishing RNA and protein expressions in specific cell subpopulations within colorectal and lung cancers.
- - Examination of glioblastoma multiforme (GBM) using the SPG assay reveals distinct differences in protein and RNA profiles between giant cell GBM and typical GBM, emphasizing its potential for detailed spatial analysis of complex tumors.
Article Synopsis
- Members of the Wiskott-Aldrich Syndrome protein (WASp) family activate the Arp2/3 complex to create branches in actin filaments, which are essential for various cellular processes.
- The proline-rich domain (PRD) in WASp and budding yeast Las17 has a specific role in binding to actin filaments and contributes to the nucleation of branching.
- Biochemical studies indicate that PRDs from both fission yeast Wsp1p and Las17p significantly slow down the elongation and spontaneous polymerization of actin filaments, suggesting their high affinity plays a crucial role in stimulating actin branching through the Arp2/3 complex.
Aims: We examined the effect of growth hormone (GH) counter-regulation on carbohydrate metabolism in individuals with life-long diminished insulin secretion (DIS).
Methods: Adults homozygous for the E180 splice site mutation of GHR [Laron syndrome (LS)], adults with a gain-of-function mutation in CDKN1c [Guevara-Rosenbloom syndrome (GRS)], and controls were evaluated for body composition, leptin, total and high molecular weight (HMW) adiponectin, insulin-like growth factor (IGF) axis molecules, and a 5-hour oral glucose tolerance test (OGTT), with measurements of glucose, insulin, glucagon, ghrelin, pancreatic polypeptide, gastric inhibitory peptide, glucagon-like peptide-1, peptide YY, and islet amyloid polypeptide (IAPP).
Results: Both syndromic cohorts displayed DIS during OGTT.