Evaluation of the Antiproliferative Properties of CpRu Complexes Containing N-Methylated Triazaphosphaadamantane Derivatives.

Piano-stool-{CpRu} complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA), -methyl-1,3,5-triaza-7-phosphaadamantane (mPTA), and 3,7-dimethyl-1,3,7-triaza-5-phosphabyciclo[3.3.1]nonane (dmoPTA) were evaluated as drugs against breast cancer.

Tetranuclear RuCu and RuNi complexes with nanomolar anticancer activity.

Complexes [{RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-CuCl}-μ-Cl-μ-OCH](CFSO)·(CHOH) (1) and [{RuCp(PPh)-μ-dmoPTA-1κ:2κ-,'-NiCl}-μ-Cl-μ-OH](CFSO) (2) have been synthesized and characterized. Their antiproliferative activities were assessed against six human solid tumours showing nanomolar GI values. The effects of 1 and 2 on SW1573 cells colony formation, HeLa cells action mechanism and their interaction with the pBR322 DNA plasmid were evaluated.

Study of the biological activity of photoactive bipyridyl-Ru(II) complexes containing 1,3,5-triaza-7-phosphaadamantane (PTA).

The water-soluble ruthenium complex cis-[Ru(dcbpyH)(PTAH)]Cl·3HO (1) (dcbpy = 4,4'-dicarboxy-2,2'-bipyridine; PTA = 1,3,5-triaza-7-phosphaadamantane) has been synthesized and characterised by NMR, IR spectroscopy, elemental analysis, and single-crystal X-ray diffraction. The optical properties of 1 were studied, including photoactivation under visible light, as well as its biological properties, together with those of the previously published Ru complexes cis-[Ru(bpy)(PTA)]Cl (2), trans-[Ru(bpy)(PTA)](CFSO) (3) and cis-[Ru(bpy)(HO)(PTA)](CFSO) (4) (bpy = 2,2'-bipyridine). Anticancer activities of the complexes against human lung (A549), cervical (HeLa) and prostate (PC3) carcinoma cells were evaluated under dark conditions and upon photoactivation with visible light.

Photo-generation of H by heterometallic complexes.

Multiple and different metals in a complex can accomplish single and sequential multi-step reactions, providing valuable procedures to obtain chemicals in one-pot synthetic routes. Biology has shown how cooperative catalysis is a powerful method for the synthesis of complicated molecules. One of the most attractive targets for current chemists is the synthesis of H by a simple and economical procedure, mainly if it is produced from water using visible light as the energy source.

Insights into the κ-P,N Coordination of 1,3,5-Triaza-7-phosphaadamantane and Derivatives: κ-P,N-Heterometallic Complexes and a N Nuclear Magnetic Resonance Survey.

Complexes {[(PTA)CpRu-μ-CN-1:2-RuCp(PTA)-ZnCl]}·2DMSO () {[ZnCl(HO)]-(PTA-1κ:2κ)(PTA)CpRu-μ-CN-1κ:2κ-RuCp(PTA)(PTA-1κ:2κ)-[ZnCl(HO)]}Cl (), [RuCp(HdmoPTA)(PPh)(PTA)](CFSO) (), [RuCp(HdmoPTA)(HPTA)(PPh)](CFSO) (), and [RuCp(dmoPTA)(PPh)(PTA)](CFSO) () were obtained and characterized, and their crystal structure together with that of the previously published complex is reported. The behavior of the 1,3,5-triaza-7-phosphatricyclo[3.3.