Publications by authors named "A Roichman"
Article Synopsis
- Despite extensive research, much of the mammalian metabolome is still unexplored, with mass spectrometry detecting many small molecules but revealing few identified metabolites.
- A novel approach using DeepMet, a chemical language model, has been developed to uncover previously unknown metabolites by learning the biosynthetic logic of known compounds.
- By combining DeepMet with tandem mass spectrometry, the research enables automated discovery of a wide range of metabolites, demonstrating the potential of language models to enhance our understanding of the metabolome.
Pancreatic cancer is the third leading cause of cancer death in the United States, and while conventional chemotherapy remains the standard treatment, responses are poor. Safe and alternative therapeutic strategies are urgently needed . A ketogenic diet has been shown to have anti-tumor effects across diverse cancer types but will unlikely have a significant effect alone.
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- Researchers studied the regulation of photosynthesis using the alga Chlamydomonas reinhardtii and identified 70 genes that were previously not well understood but are essential for the process.
- They analyzed mutant strains missing these genes, leading to the assignment of 34 genes involved in forming and regulating specific photosynthetic complexes.
- The study reveals new roles for several proteins in photosynthesis regulation, providing a valuable resource for understanding how photosynthesis works at a molecular level.
Tissues derive ATP from two pathways-glycolysis and the tricarboxylic acid (TCA) cycle coupled to the electron transport chain. Most energy in mammals is produced via TCA metabolism. In tumours, however, the absolute rates of these pathways remain unclear.
View Article and Find Full Text PDFThe Turkana people inhabit arid regions of east Africa-where temperatures are high and water is scarce-and they practice subsistence pastoralism, such that their diet is primarily composed of animal products. Working with Turkana communities, we sequenced 367 genomes and identified 8 regions putatively involved in adaptation to water stress and pastoralism. One of these regions includes a putative enhancer for STC1-a kidney-expressed gene involved in the response to dehydration and the metabolism of purine-rich foods such as red meat.
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