Publications by authors named "A Roers"
TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa.
J Clin Invest
January 2025
Similarly to acute intestinal helminth infection, several conditions of chronic eosinophilic type 2 inflammation of mucosal surfaces, including asthma and eosinophilic esophagitis, feature robust expansions of intraepithelial mast cells (MCs). Also the hyperplastic mucosa of nasal polyposis in the context of chronic rhinosinusitis, with or without COX1 inhibitor intolerance, contains impressive numbers of intraepithelial MCs. In this issue of the JCI, Derakhshan et al.
View Article and Find Full Text PDFIntegrin β1-mediated mast cell immune-surveillance of blood vessel content.
J Allergy Clin Immunol
September 2024
Background: IgE-mediated degranulation of mast cells (MCs) provides rapid protection against environmental hazards, including animal venoms. A fraction of tissue-resident MCs intimately associates with blood vessels. These perivascular MCs were reported to extend projections into the vessel lumen and to be the first MCs to acquire intravenously injected IgE, suggesting that IgE loading of MCs depends on their vascular association.
View Article and Find Full Text PDFArticle Synopsis
- Some diseases called type I interferonopathies happen when our body wrongly senses certain RNA, leading to too much of a chemical called type I interferon.
- Researchers found that people with these diseases have fewer special immune cells called regulatory T cells.
- In experiments with mice, they saw that messing with the genes that help control T cells caused big problems in the immune system, like serious autoimmune diseases.
Article Synopsis
- MICA is a stress-induced ligand that activates NK and T cell responses, playing a crucial role in anti-tumor immunity.
- The study found high frequencies of duplications (1%) and deletions (0.4%) of the MICA gene across over two million individuals, with significant variations among different ethnic groups, reaching up to 9.2% in Mexico.
- The findings suggest that these copy number variations result from independent recombination events and highlight the need for more research on their potential links to diseases, particularly in cancer studies.