Humanizing the Transgressor and Lightening the Immoral Behavior: The Role of Likeability Bias and Moral Rationalization.

People often perceive their moral judgments as objective and unbiased, yet research indicates that positive interpersonal attitudes lead to more lenient moral character assessments. Here we investigate how likeability towards moral transgressors and the different moral rationalization strategies they may employ impact both the perceived severity of the immoral behavior and the attribution of humanity to the transgressor. In two studies, participants ( = 475) engaged in a 2 (likeability towards the transgressor: high vs.

Angiotensin type-1 receptor autoantibodies promote alpha-synuclein aggregation in dopaminergic neurons.

Angiotensin, through its type-1 receptor (AT1), is a major inducer of inflammation and oxidative stress, contributing to several diseases. Autoimmune processes have been involved in neurodegeneration, including Parkinson's disease (PD). AT1 autoantibodies (AT1-AA) enhance neurodegeneration and PD, which was related to increased neuronal oxidative stress and neuroinflammation.

Modulation of Mitochondrial Dynamics by the Angiotensin System in Dopaminergic Neurons and Microglia.

Renin-angiotensin system (RAS) dysfunctions have been associated to life-spam, and aging-related diseases, including neurodegenerative diseases, such as Parkinson's disease, and the neuroinflammatory associated processes. Mitochondrial dysfunctions play a major role in aging-related diseases, including dopaminergic neurodegeneration and neuroinflammation. However, the mechanisms of RAS/mitochondria interactions remain to be clarified.

Withdrawal/Withholding of Life-Sustaining Therapies: Limitation of Therapeutic Effort in the Intensive Care Unit.

: The change in critically ill patients makes limitation of therapeutic effort (LTE) a widespread practice when therapeutic goals cannot be achieved. We aimed to describe the application of LTE in a post-surgical Intensive Care Unit (ICU), analyze the measures used, the characteristics of the patients, and their evolution. Retrospective observational study, including all patients to whom LTE was applied in a postsurgical ICU between January 2021 and December 2022.