Publications by authors named "A Rodriguez-Largo"
Article Synopsis
- Persistent subcutaneous granulomas develop at the injection site after administering aluminium oxyhydroxide (AlOOH), a common vaccine adjuvant, and can facilitate the infection of macrophages by small ruminant lentiviruses (SRLVs) in sheep.
- The study involved 24 male lambs that underwent vaccination followed by SRLV infection, revealing that the granulomas, initially large, decreased in size over time and exhibited various features including central necrosis and keratin presence.
- The research highlighted significant differences in the expression of the mannose receptor and the restriction factor A3Z1 in relation to the vaccine type and time, suggesting that macrophage polarization might affect SRLV infection, though the overall structure of the granulomas remained
Antibiotics, specifically clindamycin (Clin), cause intestinal dysbiosis, reducing the microbiota with anti-inflammatory properties. Furthermore, Clin can induce alterations in the immune responses and oxidative stress. Lactoferrin, among other activities, participates in the maintenance of intestinal homeostasis and reduces dysbiosis induced by antibiotic treatment.
View Article and Find Full Text PDFInflammatory bowel disease is a gut-brain axis disorder that comprises chronic inflammatory conditions affecting the gastrointestinal tract, where alterations in the mood of patients are common. Gut-brain axis is a bidirectional communication that link gut and brain. The close association between inflammatory bowel disease and neuroinflammation has far-reaching implications, as is increasingly recognized as a contributing factor to neuropsychiatric and neurodegenerative diseases.
View Article and Find Full Text PDFArticle Synopsis
- - The study examines the unique corrugated intimal surface found in the thoracic aorta of sheep, contrasting it with the smooth surface observed in healthy animals.
- - A total of 24 aortas from various animals were analyzed, and the corrugated pattern was consistently identified in sheep and a goat but was less prominent in cattle.
- - Histological analysis revealed that the intimal surface in sheep shows bulging areas and muscle islands that disrupt normal structure, but these features are physiological rather than pathological.