Publications by authors named "A Rocabado Morato"
Article Synopsis
- The incorporation of fluorinated amino acids into proteins allows for better understanding of biomolecular structures and functions.
- A new method for site-specific integration of fluoroprolines into proteins has been developed, tested on a non-pathogenic version of the huntingtin protein.
- Experimental findings reveal that the effects of fluoroproline variants on protein structure vary based on factors like stereochemistry and the specific amino acid sequence, with insights supported by molecular dynamics simulations.
Article Synopsis
- Maternal HIV and malaria infections during pregnancy can negatively impact the transfer of pertussis immunity from mothers to their infants.
- A study in Mozambique, involving 270 mother-infant pairs, found that mothers with HIV had significantly lower placental transfer of pertussis-specific antibodies compared to those without HIV.
- The findings suggest that addressing maternal HIV through healthcare interventions and immunization could help protect infants from pertussis.
Assisted reproductive technologies (ARTs) involve the laboratory manipulation of gametes and embryos to help couples with fertility problems become pregnant. One of these procedures, controlled ovarian stimulation, uses pharmacological agents to induce ovarian and follicular maturation in vivo. Despite the effectiveness in achieving pregnancy and live births, some patients may have complications due to over-response to gonadotropins and develop ovarian hyperstimulation syndrome.
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- Scientists don't know much about vulvar squamous cell carcinoma (VSCC), a cancer mostly found in older women, especially about its mutations and how different types affect survival.
- In a study of 60 patients, they found three main types of VSCC related to the human papillomavirus (HPV) and some common gene mutations, particularly in the TP53 gene.
- Patients with mutations in TP53 and CCND1 had a much higher chance of their cancer coming back, suggesting that these changes could help doctors find better treatments for VSCC.