Participatory research in child psychology & psychiatry: Embracing untidiness to break new ground.

We are pleased to present our Special Issue on Participatory Research. In this editorial, we outline how the disability rights movement has been instrumental to the development of participatory approaches, before giving consideration to some of the debates and criticisms associated with participatory research in practice. We summarise the contributions offered by the studies within this issue and propose four areas of consideration, drawn from the body of included research, to inform future developments.

Dynamic assessment, more than a diagnostic tool? Uses for goals, teaching moments, and procedural issues during intervention of speech sound disorder.

Dynamic assessment is typically used for diagnostic and baseline purposes; however, the current study explored expanding the use of dynamic assessment as a curriculum-based measure to additionally capture teaching moments and observe intervention elements during treatment of speech sound disorder (NCT06075303). Teaching moments occur when an SLT presents an antecedent, the child produces a behaviour, and the SLT responds with a consequence related to accuracy; yet, little is known about the characteristics of these elements that are the most essential for improving treatment outcomes. To address this gap, we used the Glaspey Dynamic Assessment of Phonology's scoring system to establish the goal, code teaching moments, describe procedural issues, and evaluate children's skill development.

Novel Macrocyclic NLRP3 Inhibitors.

Aberrant activation of NLRP3 due to persistent tissue damage, misfolded proteins or crystal deposits has been linked to multiple chronic inflammatory disorders such as cryopyrin-associated periodic syndrome (CAPS), neurodegenerative diseases, gouty arthritis, and numerous others. Hence, there has been an increasing interest in NLRP3 inhibitors as therapeutics. A first generation of NLRP3 inhibitors bearing a sulfonylurea core such as MCC950 (developed by Pfizer) were discovered by phenotypic screening, however their mode of action was only elucidated later.

Evaluation of the epidemiological situation of intestinal schistosomiasis using the POC-CCA parasite antigen test and the Kato-Katz egg count test in school-age children in endemic villages in western Côte d'Ivoire.

Schistosomiasis is an endemic disease in Côte d'Ivoire. We compared the conventional Kato Katz (KK) test and a more sensitive but rarely used method, the point-of-care circulating cathodic antigen (POC-CCA), in order to contribute to the development of a more appropriate strategy for the control and elimination of intestinal schistosomiasis in western Côte d'Ivoire. A cross-sectional epidemiological survey was conducted in eight elementary schools in the Guémon and Cavally regions from February to December 2020.