Simple Climate Models That Can Be Used in Primary, Secondary, and Tertiary Education.

Climate change is of great concern to all age groups but in particular to children. "Simple" climate models have been in place for a long time and can be used effectively with post-16 students. For younger children, modifications are required, and we describe in this paper the development and use of two such models.

Engaging and supporting the public on the topic of grief and bereavement: an evaluation of Good Grief Festival.

Background: Good Grief Festival was originally planned as a face-to-face festival about grief and bereavement. Due to COVID-19, it was held online over 3 days in October 2020.

Objective: To evaluate the festival's reach and impact.

HS regulation of iron homeostasis by IRP1 improves vascular smooth muscle cell functions.

Either HS or iron is essential for cellular processes. Abnormal metabolism of HS and iron has increased risk for cardiovascular diseases. The aim of the present study is to examine the mutual interplay of iron and HS signals in regulation of vascular smooth muscle cell (SMC) functions.

How are public engagement health festivals evaluated? A systematic review with narrative synthesis.

The evaluation of public engagement health festivals is of growing importance, but there has been no synthesis of its practice to date. We conducted a systematic review of evidence from the evaluation of health-related public engagement festivals published since 2000 to inform future evaluation. Primary study quality was assessed using the Mixed Methods Appraisal Tool.

Deficiency of cystathionine gamma-lyase promotes aortic elastolysis and medial degeneration in aged mice.

Enzymatic degradation of elastin by matrix metalloproteinases (MMPs) leads to the permanent dilation of aortic wall and constitutes the most prominent characters of aortic aneurysm and aging-related medial degeneration. Hydrogen sulfide (HS) as a gasotransmitter exhibits a wide variety of cardio-protective functions through its anti-inflammatory and anti-oxidative actions. Cystathionine gamma-lyase (CSE) is a main HS-generating enzyme in cardiovascular system.