Publications by authors named "A Rishi"
Introduction: Solid pseudopapillary neoplasm (SPN) is a tumor of young females with gain-of-function mutation in catenin beta 1 gene involved in Wnt signal transduction pathway. Beta-catenin immunohistochemistry (IHC) is used to diagnose SPN. Lymphoid enhancer-binding factor 1 (LEF-1) has been recognized in the transactivation of Wnt pathway.
View Article and Find Full Text PDFBackground/aim: Low selectivity and high frequency of side-effects are the major problems of currently used chemotherapeutics. Among natural compounds, the polyprenylated acylphloroglucinol, guttiferone E, isolated from Brazilian red propolis, has attracted attention due to its marked anticancer properties and was evaluated here for its role against osimertinib-resistant H1975 cells (with double mutations of epidermal growth factor receptor: EGFR L858R/T790M).
Materials And Methods: Guttiferone E was obtained from red propolis using established extraction procedures.
Long noncoding RNAs in ubiquitination, protein degradation, and human diseases.
Biochim Biophys Acta Gene Regul Mech
December 2024
Article Synopsis
- Protein stability and turnover are vital for normal cellular functions, and their misregulation can lead to various health issues like neurodegeneration and metabolic dysfunction.
- Long non-coding RNAs (lncRNAs) are large, non-protein-coding molecules that play significant roles in metabolism, cellular homeostasis, and protein regulation, affecting cell signaling and protein degradation.
- The article reviews the emerging importance of lncRNAs in regulating protein polyubiquitination and proteasomal degradation processes, suggesting their potential as biomarkers and therapeutic targets in diseases such as cancer and neurological disorders.
IgG4-related disease (IgG4-RD) is an autoimmune syndrome that is characterized by elevated levels of serum IgG4 and infiltration of various tissue types by IgG4 immunoreactive plasma cells. The IgG4-RD can result in systemic disease and the formation of inflammatory mass lesions, frequently addressed as pseudotumors. While IgG4-RD can manifest in various organs, liver involvement is rare, and because it is an immune-mediated inflammatory process, it is uncommon in patients who are immunocompromised.
View Article and Find Full Text PDFObjectives: Stereotactic body radiotherapy (SBRT) is widely used for localized prostate cancer and implementation of MR-guided radiotherapy has the advantage of tighter margins and improved sparing of organs at risk. Here we evaluate outcomes and time required to treat using non-adaptive MR-guided SBRT (MRgSBRT) for localized prostate cancer at our institution.
Methods: From 9/2019 to 11/2021 we conducted a retrospective review of 80 consecutive patients who were treated with MRgSBRT to the prostate.