[Indomethacin enema in treatment of postoperative pain after knee arthrotomy. A double-blind controlled trial].

Twenty-three patients subjected to arthrotomy of the knee were in a double-blind trial randomly allocated to either: 1) Indomethacin 100 mg (Confortid) administered as an enema immediately before induction of anaesthesia and repeated morning and evening for the next two days, or: b) a placebo. The patients' demand for postoperative pain treatment were registered. Survival analysis was applied to the time passed from recovery from anaesthesia until patients first asked for postoperative pain treatment.

Prophylactic ephedrine during spinal anaesthesia: double-blind study in patients in ASA groups I-III.

Forty-eight patients scheduled to undergo spinal anaesthesia were allocated to three groups of 16 each according to ASA classification I-II-III. Each patient received a fluid load of 7 ml kg-1 and either ephedrine 12.5 mg i.

Prediction of severe postoperative complications in patients admitted to neuroanaesthesia.

The purpose of this study was to identify factors which will predict the risk of severe postoperative complications in individual patients in a neurosurgical unit. Eleven risk factors were investigated in 363 neurosurgical patients, of whom 40 (11%) developed postoperative complications requiring mechanical ventilation for more than 24 h in an intensive care unit, 16 were found to be severely disabled or in a vegetative state at follow-up 1 month after admission, and 28 patients died. By applying stepwise, logistic regression analysis to the patient's data, we were able to select two significant risk variables, i.

Buprenorphine antagonism of ventilatory depression following fentanyl anaesthesia.

In order to compare the effect of buprenorphine and naloxone on respiratory depression after fentanyl anaesthesia (25 micrograms/kg), 32 women scheduled for elective abdominal hysterectomy participated in a double-blind randomized investigation. At termination of anaesthesia, after antagonizing residual neuromuscular blockade, 20 normocapnic patients with a respiratory rate of 4 breaths/min or less entered the study, receiving either buprenorphine (0.6 mg in 20 ml NaCl) or naloxone (0.