The Interplay Between Replication Capacity of HIV-1 and Surrogate Markers of Disease.

Background: HIV-1 replication capacity (RC) of transmitted/founder viruses may influence the further course of HIV-1 infection.

Methods: RCs of 355 whole-genome primary HIV-1 isolates derived from samples acquired during acute and recent primary HIV-1 infection (PHI) were determined using a novel high-throughput infection assay in primary cells. The RCs were used to elucidate potential factors that could be associated with RC during PHI.

A Novel High Throughput, Parallel Infection Assay for Determining the Replication Capacities of 346 Primary HIV-1 Isolates of the Zurich Primary HIV-1 Infection Study in Primary Cells.

HIV-1 replication capacity is an important characteristic to understand the replication competence of single variants or virus populations. It can further aid in the understanding of HIV-1 pathogenicity, disease progression, and drug resistance mutations. To effectively study RC, many assays have been established.

Periodontal conditions following surgical and orthodontic treatment of palatally impacted maxillary canines--a follow-up study.

This follow-up study reports on the periodontal status 1 to 18 years after the completion of orthodontic treatment of unilateral palatally impacted maxillary canines and their adjacent incisors and premolars. Registrations were performed on 42 patients, 19 to 59 years old (mean 35 years) at investigation. An orthodontic pin with eyelet had been placed after exploration of the canine and, in some cases, bone removal.

Early surgical-orthodontic treatment of mandibular hypoplasia in juvenile chronic arthritis.

This study is an intermediate evaluation of early surgical-orthodontic treatment in 7 patients with uni- or bilateral hypoplastic mandibular growth due to juvenile chronic arthritis. Resection of the condylar heads and reconstruction with costochondral grafts was undertaken between 10 and 14 years of age and followed by orthodontic treatment. At the latest follow-up, 2-4.

Orthodontic and surgical treatment of unilateral condylar hyperplasia during growth--a case report.

A 9-year-old boy was diagnosed as having an unilateral cross-bite with mandibular deviation. This was later found to be due to unilateral hyperplasia of the right condyle. The increased growth activity subsequently led to an extreme facial asymmetry and a serious psychological condition began to develop.