IFI16 Expression Is Related to Selected Transcription Factors during B-Cell Differentiation.

The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation.

Patients' survival after free flap reconstructive surgery of head and neck squamous cell carcinoma: a retrospective multicentre study.

Head and neck squamous cell carcinoma of the (HNSCC) represents approximately 5% of malignant tumours in Italy. HNSCC are commonly treated with surgery or radiotherapy, or a combination of such therapies. The objectives of treatment are maximum cure rate balanced with organ preservation, restoration of form and function, reduction of morbidities and improvement or maintenance of the patient's quality of life.

Synovial chondromatosis of the middle ear: a case report.

Synovial chondromatosis is a rare pathology of unknown etiology characterized by multinodular cartilaginous proliferation in the synovium. When it does occur, it usually develops in the large synovial joints (e.g.

Comparative evaluation of ABR abnormalities in patients with and without neurinoma of VIII cranial nerve.

Although the diagnostic reliability of auditory brainstem responses (ABR) in acoustic neuromas has been revised due to its poor sensitivity (demonstrated above all in smaller tumours), and its limited specificity, this method is still used as the initial otoneurological approach. To contribute to the clinical use of this method, in particular with the aim of reducing the number of false positives, a retrospective study was carried out in two groups of patients affected by unilateral sensorineural hearing loss with auditory brainstem response abnormalities: in the first group (50 cases: true positives) hearing loss was the expression of an acoustic neuroma shown by magnetic resonance imaging, in the second group (130: false positives) magnetic resonance imaging was negative. In both groups, auditory brainstem response recordings showed abnormalities suggesting retro-cochlear disorders such as: (1) complete absence of response not justified by the extent of the hearing loss, (2) presence of only wave I, (3) increase in wave V absolute latency with normal I-V interpeak latency, (4) increase in wave V absolute latency, the sole component, 5) increase in wave V absolute latency and I-V interpeak latency.

Foreign bodies in the upper airways: the experience of two Italian hospitals.

Objective: To study the pattern of foreign bodies in the upper airways as emerging from the hospital records in the Bologna and Siena hospitals in Italy 1997-2002.

Methods: A retrospective review of hospital records was performed using a standardized protocol. All injuries with ICD9 (International Classification of Diseases, 9'h revision) codes ranging from 931 to 934 which occurred in children age 0-14 were considered for the database.