Barriers and facilitators for the implementation of delayed-prescription of antibiotics in family medicine: a qualitative study.

Background: Delayed prescription is a strategy used in various countries to reduce antibiotic overuse and contend the effects of antibiotic resistance; however this practice is not yet used in Switzerland. The present qualitative study was thus conducted to investigate Swiss patients' attitudes towards the possible implementation of delayed prescription.

Method: Five focus groups with the general population based on a fixed script of questions to elicit opinions on delayed prescription.

Application of Microsponge Drug Platform to Enhance Methotrexate Administration in Rheumatoid Arthritis Therapy.

Background/objectives: This study aimed to develop a novel nanotechnological slow-release drug delivery platform based on hyaluronic acid Microsponge (MSP) for the subcutaneous administration of methotrexate (MTX) in the treatment of rheumatoid arthritis (RA). RA is a chronic autoimmune disease characterized by joint inflammation and damage, while MTX is a common disease-modifying antirheumatic drug (DMARD), the conventional use of which is limited by adverse effects and the lack of release control.

Methods: MSP were synthesized as freeze-dried powder to increase their stability and allow for a facile reconstitution prior to administration and precise MTX dosing.

Anti-aquaporin-5 and anti-poly-U-binding-factor-60kDa protein antibodies in primary Sjögren's disease patients: preliminary data and correlation with disease activity indices.

Objectives: In primary Sjögren's disease (pSjD), in addition to glandular inflammation and atrophy, functional secretion impairment may contribute to dryness. Altered protein distribution and antibodies against aquaporin-5 (anti-AQP5) and poly-U-binding factor 60kDa protein (anti-PUF60) have been reported in pSjD and may be specifically implicated in the glandular secretive processes. This study aimed to assess the occurrence of serum anti-AQP5 and anti-PUF60 antibodies and their correlations with clinical and laboratory features of pSjD.

[Poorer countries have more pro-breastfeeding actions than rich countries: ecological study of 98 countries].

This study aimed to verify the association between gross domestic product values - purchasing power parity (GDP PPP) and scores of the World Breastfeeding Trends Initiative (WBTi) tool. This is an ecological study carried out with 98 low-income (n = 43), middle-income (n = 27), and high-income (n = 28) countries. The evaluation of pro-breastfeeding actions was obtained from the WBTi and the GDP PPP from the World Bank.

Neuroregenerative Effects of Radio Electric Asymmetric Conveyer (REAC) Neuroregenerative (RGN-N) Therapy in Pediatric Adrenoleukodystrophy: A Case Report.

This case report presents the use of radio electric asymmetric conveyer (REAC) neuroregenerative (RGN-N) therapy in a pediatric patient with adrenoleukodystrophy (ALD), a progressive neurodegenerative disorder with limited therapeutic options. The patient underwent three REAC RGN-N treatment cycles, each lasting 72 hours, with approximately 6-7 hours of daily sessions. An asymmetric conveyor probe (ACP) was positioned along the spine to channel the interaction of the emitted radio electric field with cellular electro-metabolic alterations, promoting progressive bioelectrical restoration.