The contribution of cognitive disengagement syndrome symptoms to depressive symptoms among pediatric brain tumor survivors.

Objective: Pediatric brain tumor survivors (PBTS) are at risk for neurocognitive late effects that can resemble symptoms of cognitive disengagement syndrome (CDS). In the current study, we compared the CDS symptoms of PBTS to those of healthy comparison classmates (CC) and examined whether CDS might explain group differences in depressive symptoms. We also explored whether CDS symptoms were associated with engagement-based coping strategies and stress responses, thereby testing one mechanism by which CDS could lead to affective difficulties.

Association of Structural Maintenance of Chromosome-1A Phosphorylation with Progression of Breast Cancer.

Structural maintenance of chromosome-1A (SMC1A) is overexpressed in various malignancies including triple-negative breast cancer (TNBC). As a core component of the cohesin complex, SMC1A was initially recognized for its involvement in chromosomal cohesion and DNA-repair pathways. However, recent studies have unveiled its pivotal role in epithelial-mesenchymal transition (EMT), metastasis, and chemo- and radio-resistance in cancer cells.

Multi-omics analysis of long-term cultured human islets.

β-cell dysfunction in pancreatic islets, characterized as either the loss of β-cell mass or the resistance of β-cell to glucose, is the leading cause of progression to diabetes. Islet transplantation became a promising approach to replenish functional β-cell mass. However, not much known about changes in islets used for transplantation after isolation.

Happy Normativists: Do Children Express Happiness When Following Conventional Norms?

Young children rapidly acquire and rigidly adhere to conventional norms. Prior accounts of this early-emerging norm behavior propose that children perceive conventional norms as obligations to their cultural groups and, in conforming to the norms, sacrifice their individual desires for the welfare of the group. In the current research, we investigate the hypothesis that children may actually derive happiness from adhering to conventional norms, thus aligning rather than diverging from their individual desires.