Publications by authors named "A Rick"
Background: Treatment of hepatitis C virus (HCV) during pregnancy can cure maternal HCV and prevent perinatal HCV transmission. The primary objective was to compare the pharmacokinetics (PK) of sofosbuvir/velpatasvir (SOF/VEL) in pregnant versus nonpregnant people.
Methods: Pregnant people with chronic HCV infection were enrolled between 23-25 weeks' gestation and were provided SOF/VEL daily for 12 weeks.
Factors Associated With Nonprescription of Oseltamivir for Infant Influenza Over 9 Seasons.
J Pediatric Infect Dis Soc
September 2024
Article Synopsis
- The CDC recommends oseltamivir phosphate for infants under 2 years with confirmed or suspected influenza, as they face high risks for complications.
- A 9-year study at the University of Pittsburgh Medical Center analyzed 457 infants under 12 months and found 86% were prescribed oseltamivir, with prescription rates increasing from 64.6% to 90.4% over two time periods.
- Factors leading to nonprescription included longer symptom duration, earlier diagnosis years, positive multiplex PCR tests, and lack of fever at the doctor's visit, indicating potential areas for improving prescribing practices.
Pediatric Hepatitis C Screening by Maternal Hepatitis C Infection Status During Pregnancy.
J Pediatric Infect Dis Soc
September 2024
Background: Screening for perinatal hepatitis C virus (HCV) infections remains low despite increases in the number of at-risk infants. It is unknown if pediatric screening varies by maternal HCV infection status during pregnancy.
Methods: Using a retrospective cohort of mother-infant pairs born from 2015 to 2019, we identified women with HCV and classified their infection status during pregnancy as active, probable, or previous based on HCV RNA testing obtained during pregnancy.
Article Synopsis
- * The Centers for Disease Control and Prevention recommends these vaccines to help reduce the risk of severe complications during pregnancy and early infancy.
- * Research shows that these vaccines are safe and effective, allowing mothers to pass on protective antibodies to their babies, boosting their immunity in the first months of life.
Objectives: To report novel biallelic variants in a family presenting with pure hereditary spastic paraparesis.
Methods: Two affected sisters presented with unsolved hereditary spastic paraparesis and underwent clinical and imaging assessments. This was followed by short-read next-generation sequencing.