Publications by authors named "A Richter-Unruh"
Endocrine management of transgender and gender diverse adolescents: expert opinion of the ESPE Working Group on Gender Incongruence and the Endo-ERN main thematic group on Sexual Development and Maturation.
Horm Res Paediatr
December 2024
Increasing numbers of transgender and gender diverse adolescents seek endocrine treatment to align their body to their gender identity. In this relatively young field of medicine, there is a limited body of evidence, and the available evidence generally is of low quality. However, in the absence of randomised trials, much can be learned from prospective observational studies.
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- The study explores how overexpressing FGF23 affects SaOS-2 cells, particularly regarding stress responses and morphology, and its relation to skeletal disorders like X-linked hypophosphatemia (XLH).
- Researchers utilized transmission electron microscopy and protein analysis to observe changes in the rough endoplasmic reticulum (rER) and mitochondria of these cells, noting significant alterations such as enlargement and increased contact zones.
- The findings indicate higher rates of apoptosis and activation of pathways related to cellular stress, suggesting that FGF23 overexpression plays a critical role in how cells manage protein synthesis demands and stress, paving the way for potential therapeutic strategies for related diseases.
S2k-Guideline Non-hormonal Contraception, Part 2: Intrauterine Devices and Sterilization: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015 - 095, January 2024).
Geburtshilfe Frauenheilkd
August 2024
This official guideline was published and coordinated by the DGGG, OEGGG and SGGG with the involvement of other medical societies. The aim was to provide a consensus-based overview of non-hormonal forms of contraception based on an evaluation of the relevant literature. The first part of these summarized statements and recommendations presents natural family planning methods such as lactational amenorrhea, barrier methods and coitus interruptus.
View Article and Find Full Text PDFS2k-Guideline Non-hormonal Contraception, Part 1: Natural Family Planning, Lactational Amenorrhea, Barrier Methods, Coitus Interruptus: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015 - 095, January 2024).
Geburtshilfe Frauenheilkd
August 2024
This official guideline was published and coordinated by the DGGG, OEGGG and SGGG with the involvement of other medical societies. The aim was to provide a consensus-based overview of non-hormonal forms of contraception based on an evaluation of the relevant literature. The first part of these summarized statements and recommendations presents natural family planning methods such as lactational amenorrhea, barrier methods and coitus interruptus.
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- The study evaluated a new interdisciplinary education program aimed at children, adolescents, and young adults with differences of sex development (DSD) and their parents, focusing on participant satisfaction.
- The program included tailored medical information, peer support, and psychological assistance over two days, with satisfaction measured using an adapted ZUF-8 questionnaire, revealing consistently high scores across all age groups and parental participants.
- The findings suggest that the program was well-received regardless of age or diagnosis, and highlight the need for further analysis on its long-term impact on participants’ well-being and knowledge.