Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.

Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studies. Here we report a genome-wide association study meta-analysed for 3 European cohorts comprising 8,011 individuals, covering both people with type 1 diabetes and general population settings.

A High-Throughput Immune-Oncology Screen Identifies Immunostimulatory Properties of Cytotoxic Chemotherapy Agents in TNBC.

Triple-negative breast cancers (TNBCs) typically have a greater immune cell infiltrate and are more likely to respond to immune checkpoint inhibition (ICI) than ER+ or HER2+ breast cancers. However, there is a crucial need to optimize combining chemotherapy strategies with ICI to enhance overall survival in TNBC. Therefore, we developed a high-throughput co-culture screening assay to identify compounds that enhance CD8+ T-cell-mediated tumor cell cytotoxicity.

Utilization of Injectable and Device-Based Treatments in Medical Dermatology: A Survey on Demographics, Conditions, and Resident Involvement.

Background: Injectable and device-based treatments are used for medical dermatologic conditions, but understanding dermatologists' practices remains limited.

Objective: This study examines injectable and device-based treatments for medical dermatologic conditions to identify patterns and potential improvements.

Materials And Methods: A survey was distributed to Association of Academic Cosmetic Dermatology members, covering practice settings, conditions treated, pricing, and resident involvement.

Assessing Gender Diversity in American Society for Dermatologic Surgery Fellowship Leadership: A 2013 to 2022 Trend Analysis.

Background: While there has been improved gender representation in dermatology, there remains areas for improvement, especially in leadership positions. Studies have evaluated diversity in various dermatology subspecialties, but evaluation of gender diversity in cosmetic dermatology is lacking.

Objective: To evaluate the temporal trends in gender diversity within the American Society for Dermatologic Surgery (ASDS) Cosmetic Dermatologic Surgery Fellowship Programs from 2013 to 2022.

Imposing vs finding unity.

The target article argues that embodied cognitive neuroscience converges on a mechanistic approach to explanation. We argue that it does not. Even some of the article's for embodied cognitive neuroscience are explicitly non- or anti-mechanistic.