Publications by authors named "A Ricardo"
Rationale & Objective: Matrix metalloproteinase 2 (MMP-2) plays an important role in the development of fibrosis, the final common pathway of chronic kidney disease (CKD). This study aimed to assess the relationship between repeated measures of MMP-2 and CKD progression in a large, diverse prospective cohort.
Study Design: In a prospective cohort of Chronic Renal Insufficiency Cohort (CRIC) participants (N = 3,827), MMP-2 was measured at baseline.
The exopolymer (ESPp) was obtained from IDN-EC, composed of a polyglutamic acid and polyglycerol phosphate chain O-substituted with αGal moieties (αGal/αGlcNH 3:1 molar ratio) and with a 5000 Da molecular weight. The cytotoxicity activity of EPSp was determined by reducing the MTT (3-[4,5-dimethyl-thiazol-2-yl]-2,5-diphenyltetrazolium bromide) to formazan on HeLa cells. This EPS did not show cytotoxicity against the tested cell line.
View Article and Find Full Text PDFRationale & Objective: The risk implications of the Kidney Disease: Improving Global Outcomes (KDIGO) chronic kidney disease classification in older adults are controversial. We evaluated the risk of adverse outcomes in this population across categories of estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio (UACR).
Study Design: Prospective cohort.
Article Synopsis
- The study aims to assess the impact of transanal total mesorectal excision (taTME) on fecal incontinence and various functional outcomes (defecatory, urinary, and sexual) in patients with rectal cancer.
- It was found that while initial outcomes post-surgery showed a decline in fecal continence and defecatory function, patient outcomes improved significantly by 12 months after ileostomy closure, though they did not fully recover to preoperative levels.
- Urinary function remained stable throughout the study, but both female and male sexual functions declined without signs of recovery in the follow-up period.
Background: Eye movements can reflect brain alterations and inform on the presence of motor disabilities and cognitive impairments in people with multiple sclerosis (pwMS).
Objective: The aim of the study was to determine the correlation between motor and cognitive measurements and eye movement parameters when performing the task (NBKT).
Methods: This was a cross-sectional study carried out at Ramos Mejía Hospital, a center specialized in demyelinating diseases in Buenos Aires, Argentina.