Publications by authors named "A Rianda"
Background And Aims: We aimed to characterize the epidemiologic and comorbidities profiles of patients with chronic Hepatitis D (CHD) followed in clinical practice in Italy and explored their interferon (IFN) eligibility.
Methods: This was a cross-sectional study of the PITER cohort consisting of consecutive HBsAg-positive patients from 59 centers over the period 2019-2023. Multivariable analysis was performed by logistic regression model.
Article Synopsis
- Drug-induced liver injury (DILI) from antituberculosis treatment can affect 2-28% of patients, and this study analyzes clinical cases of suspected DILI using liver biopsy.
- A retrospective study was conducted on 10 tuberculosis patients at the "Lazzaro Spallanzani" Institute from 2017 to 2022, focusing on liver damage indicators.
- Findings indicated that 50% of biopsies confirmed DILI, with various liver injury types identified, highlighting the importance of liver biopsy as a diagnostic tool while weighing its benefits and risks.
"Real world" efficacy of bulevirtide in HBV/HDV-related cirrhosis including people living with HIV: Results from the compassionate use programme at INMI Spallanzani in Rome, Italy.
HIV Med
October 2023
Objectives: We describe the preliminary results of bulevirtide compassionate use in patients with hepatitis B and delta virus (HBV/HDV)-related cirrhosis and clinically significant portal hypertension, including those living with HIV.
Methods: We conducted a prospective observational study of consecutive patients. Clinical evaluation, liver function tests, bile acid levels, HDV-RNA, HBV-DNA, hepatitis B surface antigen, and liver and spleen stiffness were assessed at baseline and after treatment months 1, 2, 3, 4, 6, 9, and 12.
Article Synopsis
- Asymptomatic individuals make up a significant portion (25-45%) of SARS-CoV-2 infections, particularly among those on mild immunosuppressive therapy, leading to potential extended virus spread.
- A study involving 278 liver transplant recipients in Central Italy found that serology testing every four months effectively increased infection detection rates, revealing that 31 individuals had either past or active SARS-CoV-2 infections.
- The research indicated that factors like gender and kidney function affected the likelihood of being asymptomatic, and the overall anti-SARS-CoV-2 seroprevalence among liver transplant recipients was similar to the general population in the region (11.2%).
Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital.
Int J Infect Dis
April 2021
Article Synopsis
- The study analyzed COVID-19 patients in a hospital in Italy to explore factors influencing prolonged SARS-CoV-2 RNA shedding and viral clearance.
- It found that patients with comorbidities, lymphopenia, or moderate/severe respiratory issues had lower chances of viral clearance, with a median viral shedding duration of 18 days.
- Achieving viral clearance significantly improved clinical recovery rates and reduced the risk of death or the need for mechanical ventilation, emphasizing the necessity for timely hospital admission for symptomatic patients.