Publications by authors named "A Rezazadeh Ardabili"
Objective: To determine whether neighborhood-level social determinants of health (SDoH) influence mortality following sepsis in the United States.
Study Setting And Design: Retrospective analysis of data from 4.4 million hospitalized patients diagnosed with sepsis, identified using International Classification of Diseases-10 codes, across the United States.
Article Synopsis
- Sepsis is a serious condition caused by an uncontrolled immune response to infection, significantly increasing the risk of death in hospitals, making early detection vital, especially outside ICUs where traditional methods often fail.
- A new deep learning model was developed using data from over 83,000 patients, designed specifically for non-ICU environments, achieving high accuracy in predicting sepsis 24, 12, and 6 hours prior to onset with reduced false alarms.
- The model's effectiveness was confirmed by external validation, demonstrating a significant decrease in false positives, which could lead to better resource allocation in hospitals and more timely patient care.
Mental health profoundly impacts inflammatory responses in the body. This is particularly apparent in inflammatory bowel disease (IBD), in which psychological stress is associated with exacerbated disease flares. Here, we discover a critical role for the enteric nervous system (ENS) in mediating the aggravating effect of chronic stress on intestinal inflammation.
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