Background: In recent years, medical practice has followed two different paradigms: evidence-based medicine (EBM) and values-based medicine (VBM). There is an urgent need to promote medical education that strengthens the relationship between these two paradigms. This work is designed to establish the foundations for a continuing medical education (CME) program aimed at encouraging the dialogue between EBM and VBM by determining the values relevant to everyday medical activities.
View Article and Find Full Text PDFBackground: There is controversy on the safety of inhibitors of cyclooxygenase administered at high doses; however, these drugs have been reported to be effective in the prevention of a variety of human cancers. To determine if celecoxib influences cellular growth, we evaluated several effects in ovarian carcinoma cell lines.
Methods: CAOV3, OVCAR3 and SKOV3 cell lines were exposed to different concentrations of celecoxib (0-100 microM) for 24-96 h.
Objective: To determine DNA fragmentation and several molecules associated with apoptosis or proliferation in ovaries of patients with diminished ovarian reserve.
Design: Cross-sectional analysis.
Setting: Tertiary institutional hospital.
Background: Some cytokines that take part in the ovarian cycle regulation, such as IL-1beta, IL-6 and TNF-alpha play an important role during growth and development of ovarian follicle. Quantification of some cytokines is promissory in the work-up of ovarian reproductive pathology.
Objective: To determine serum levels of IL-1beta, IL-6 and TNF-alpha in infertile patients with ovarian dysfunction and to compare them with those found in ovulatory patients.