This study investigates the toxic effects of microplastics by assessing bioaccumulation, hematological parameters, and antioxidant responses in juvenile Korean bullhead (Pseudobagrus fulvidraco) exposed to polyamide microplastics (PA-MPs). The increasing release of plastics into aquatic environments leads to their degradation into microplastics, which pose a significant threat to freshwater ecosystems. To evaluate these impacts, P.
View Article and Find Full Text PDFBackground: The parkin-interacting substrate (PARIS, also known as ZNF746) is a transcriptional repressor, whose accumulation and phosphorylation play central pathological roles in Parkinson's disease (PD). PARIS-induced transcriptional repression of PGC-1α or MDM4 contributes to mitochondrial dysfunction and p53-dependent neuron loss in PD. Despite the important role of PARIS in PD pathogenesis, unbiased transcriptomic profiles influenced by PARIS accumulation in dopaminergic neurons remain unexplored.
View Article and Find Full Text PDFLamin B1, a crucial component of the nuclear lamina, plays a pivotal role in chromatin organization and transcriptional regulation in eukaryotic cells. While recent studies have highlighted the connection between Lamin B1 and RNA splicing regulation, the precise molecular mechanisms remain elusive. In this study, we demonstrate that Lamin B1 depletion leads to a global reduction in splicing factor expression, as evidenced by analysis of multiple RNA-seq datasets.
View Article and Find Full Text PDFThe endoplasmic reticulum (ER) stress response controls the balance between cellular survival and death. Here, we implicate SCOTIN, an interferon-inducible ER protein, in activating the ER stress response and modulating cell fate through its proline-rich domain (PRD)-mediated cytosolic condensation. SCOTIN overexpression leads to the formation of condensates enveloping multiple layers of the ER, accompanied by morphological signs of organelle stress.
View Article and Find Full Text PDFOpioids initiate dynamic maladaptation in brain reward and affect circuits that occur throughout chronic exposure and withdrawal that persist beyond cessation. Protracted abstinence is characterized by negative affective behaviors such as heightened anxiety, irritability, dysphoria, and anhedonia, which pose a significant risk factor for relapse. While the ventral tegmental area (VTA) and mu-opioid receptors (MORs) are critical for opioid reinforcement, the specific contributions of VTA neurons in mediating protracted abstinence-induced negative affect is not fully understood.
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